HitPredict

Interactor 1: RUFY3 (Q7L099)
Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar)
Gene: RUFY3

Interactor 2: RUFY1 (Q96T51)
RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12)
Gene: RUFY1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 33961781, 36282215
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RUN~RUN
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 469 Hs			1 708
+	Hs
		1302737 RUFY1_HUMAN (60-467): 1.53e-71: 241: 55.21		RUFY1_HUMAN (1-708): 9.63e-73: 251: 100.00
+	Hs
		1183384 RUFY3_HUMAN (1-469): 2.74e-116: 351: 100.00		RUFY2_HUMAN (99-467): 1.2e-11: 70: 10.84
+	Dm
		1213082 Q8IMP2_DROME (59-446): 5.37e-70: 237: 47.89		Q8IMP2_DROME (103-698): 3.81e-47: 180: 38.86
+	Dm
		1213078 Q8IMP0_DROME (61-456): 2.86e-74: 251: 46.47		Q8IMP0_DROME (105-560): 5.94e-35: 144: 40.00
+	Hs
		1123880 RUN3B_HUMAN (62-405): 2.51e-46: 168: 22.73		RUN3A_HUMAN (98-360): 9.2e-62: 215: 25.24
+	Hs
		1137899 RUFY1_HUMAN (60-467): 1.53e-71: 241: 55.21		MRCKA_HUMAN (386-662): 9.1e-15: 80.6: 13.27
+	Hs
		724978 RUFY1_HUMAN (60-467): 1.53e-71: 241: 55.21		MYH9_HUMAN (362-667): 1.39e-14: 80.1: 15.66
+	Hs
		1067461 RUFY1_HUMAN (60-467): 1.53e-71: 241: 55.21		EEA1_HUMAN (326-667): 1.35e-11: 70.4: 11.92
+	Hs
		1263251 RUFY1_HUMAN (60-467): 1.53e-71: 241: 55.21		RUFY2_HUMAN (99-467): 1.2e-11: 70: 10.84
+	Hs
		1067451 RUFY2_HUMAN (66-467): 1.62e-68: 231: 60.34		EEA1_HUMAN (326-667): 1.35e-11: 70.4: 11.92
+	Hs
		1309816 FYCO1_HUMAN (70-465): 4.58e-62: 220: 18.32		FYCO1_HUMAN (205-666): 7.4e-10: 64.8: 10.54
+	Hs
		725095 MYH10_HUMAN (249-467): 4.89e-42: 162: 15.53		MYH10_HUMAN (79-535): 1.05e-19: 96.6: 12.18
+	Hs
		725097 MYH10_HUMAN (249-467): 4.89e-42: 162: 15.53		MYH11_HUMAN (79-552): 1.06e-19: 96.6: 13.00
+	Hs
		724687 MYH10_HUMAN (249-467): 4.89e-42: 162: 15.53		MYH9_HUMAN (362-667): 1.39e-14: 80.1: 15.66
+	Hs
		724686 MYH9_HUMAN (236-467): 2.43e-34: 139: 15.09		MYH9_HUMAN (362-667): 1.39e-14: 80.1: 15.66
+	Hs
		724810 MYH9_HUMAN (236-467): 2.43e-34: 139: 15.09		ROCK1_HUMAN (102-638): 4.76e-13: 74.9: 12.96