HitPredict

Interactor 1: MIB1 (Q80SY4)
E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1)
Gene: MIB1

Interactor 2: DLL4 (Q9JI71)
Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4)
Gene: DLL4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	16000382, 23162128
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007219 - Notch signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1006 Mm			1 686
+	Mm
		1142610 MIB1_MOUSE (1-1006): 0: 857: 100.00		DLL1_MOUSE (10-529): 4.89e-74: 254: 51.99
+	Hs
		132263 MIB1_HUMAN (1-1006): 0: 853: 99.30		DLL1_HUMAN (23-686): 2.39e-74: 255: 45.58
+	Dr
		1193380 MIB1_DANRE (1-1006): 0: 810: 90.41		DLLC_DANRE (10-686): 5.8e-68: 237: 41.00
+	Dr
		47661 A0AR23_DANRE (8-1006): 0: 757: 30.61		DLLC_DANRE (10-686): 5.8e-68: 237: 41.00
+	Mm
		291769 MIB1_MOUSE (1-1006): 0: 857: 100.00		DLL3_MOUSE (376-551): 6.25e-18: 89.9: 28.10
+	Hs
		946786 MIB1_HUMAN (1-1006): 0: 853: 99.30		CRUM1_HUMAN (159-326): 1.16e-18: 92.9: 22.51
+	Mm
		1193398 MIB1_MOUSE (1-1006): 0: 857: 100.00		JAG1_MOUSE (19-326): 1.31e-11: 70.3: 13.60
+	Dr
		1150280 MIB1_DANRE (1-1006): 0: 810: 90.41		DLLA_DANRE (308-686): 5.43e-26: 115: 20.42
+	Hs
		944122 MIB1_HUMAN (1-1006): 0: 853: 99.30		JAG1_HUMAN (19-326): 8.98e-12: 70.7: 13.60
+	Dr
		50483 MIB1_DANRE (1-1006): 0: 810: 90.41		A1L1P2_DANRE (365-677): 5.42e-25: 112: 17.57
+	Mm
		1193399 MIB1_MOUSE (1-1006): 0: 857: 100.00		JAG2_MOUSE (19-312): 2.42e-09: 63: 12.79
+	Dr
		47651 A0AR23_DANRE (8-1006): 0: 757: 30.61		DLLA_DANRE (308-686): 5.43e-26: 115: 20.42
+	Dr
		47638 A0AR23_DANRE (8-1006): 0: 757: 30.61		A1L1P2_DANRE (365-677): 5.42e-25: 112: 17.57
+	Dm
		575654 MIB_DROME (8-940): 0: 657: 62.29		SERR_DROME (172-619): 3.84e-39: 157: 21.49
+	Dm
		422915 MIB_DROME (8-940): 0: 657: 62.29		NOTCH_DROME (352-685): 1.4e-28: 125: 22.65
+	Dm
		485032 MIB_DROME (8-940): 0: 657: 62.29		DL_DROME (21-309): 1.23e-10: 66.9: 15.39
+	Hs
		1284699 MIB2_HUMAN (14-1006): 0: 587: 28.94		JAG2_HUMAN (366-686): 1.46e-25: 115: 20.43
+	Dm
		485029 Q9VJ14_DROME (15-1006): 0: 615: 32.90		DL_DROME (21-309): 1.23e-10: 66.9: 15.39
+	Dm
		65546 A8JNM5_DROME (307-844): 1.26e-108: 374: 19.97		NOTCH_DROME (352-685): 1.4e-28: 125: 22.65
+	Hs
		166914 ANR28_HUMAN (182-719): 2.18e-91: 316: 16.95		NOTC2_HUMAN (220-685): 2.28e-45: 177: 23.24