Protein: RN126
E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)

Gene: RN126, RNF126
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q9BV68

Gene Ontology (top 5):
GO:0005154 - epidermal growth factor receptor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

856896

BAG6
Large proline-rich protein BAG6

15

10

Small-scale

0.986

High

982300

UB2D2
Ubiquitin-conjugating enzyme E2 D2

9

20

Small-scale

0.970

High

906765

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

20

Small-scale

0.952

High

957181

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.923

High

508544

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

20

Small-scale

0.885

High

1414932

RN126
E3 ubiquitin-protein ligase RNF126

4

12

Small-scale

0.885

High

1414950

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.862

High

507354

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

20

High-throughput

0.861

High

543280

UBL4A
Ubiquitin-like protein 4A

2

20

Small-scale

0.768

High

1330536

UBL4B
Ubiquitin-like protein 4B

1

11

High-throughput

0.691

High

1272424

GET4
Golgi to ER traffic protein 4 homolog

4

0

High-throughput

0.670

High

294794

CAN15
Calpain-15

3

1

High-throughput

0.667

High

423839

APOD
Apolipoprotein D

3

1

High-throughput

0.667

High

1101889

SKP2
S-phase kinase-associated protein 2

3

3

High-throughput

0.667

High

1290957

TAXB1
Tax1-binding protein 1

3

7

High-throughput

0.667

High

1414940

KLH42
Kelch-like protein 42

3

1

High-throughput

0.667

High

957830

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1133316

CRYM
Ketimine reductase mu-crystallin

3

0

High-throughput

0.638

High

1327883

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

3

0

High-throughput

0.638

High

1414942

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

3

0

High-throughput

0.638

High

1330829

TSYL6
Testis-specific Y-encoded-like protein 6

2

1

High-throughput

0.628

High

1391030

OTUB1
Ubiquitin thioesterase OTUB1

2

4

Small-scale

0.625

High

808160

CDN1A
Cyclin-dependent kinase inhibitor 1

2

1

Small-scale

0.624

High

1381193

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.621

High

1397288

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.621

High

971014

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1229065

RNF43
E3 ubiquitin-protein ligase RNF43

1

7

High-throughput

0.618

High

1339840

PJA1
E3 ubiquitin-protein ligase Praja-1

1

11

High-throughput

0.618

High

1414943

UBQL2
Ubiquilin-2

1

10

High-throughput

0.618

High

224040

GET3
ATPase GET3

2

1

High-throughput

0.611

High

593611

GDC
Solute carrier family 25 member 16

3

1

High-throughput

0.609

High

1369756

RAD50
DNA repair protein RAD50

2

3

Small-scale

0.584

High

1414934

AICDA
Single-stranded DNA cytosine deaminase

1

0

Small-scale

0.561

High

363803

EGFR
Epidermal growth factor receptor

1

2

Small-scale

0.561

High

558377

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.561

High

559483

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.561

High

730861

1433S
14-3-3 protein sigma

1

11

Small-scale

0.561

High

839353

MTOR
Serine/threonine-protein kinase mTOR

1

4

Small-scale

0.561

High

1096199

TADBP
TAR DNA-binding protein 43

1

3

Small-scale

0.561

High

783398

TRI23
E3 ubiquitin-protein ligase TRIM23

1

16

High-throughput

0.541

High

983959

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.541

High

1028370

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

High-throughput

0.541

High

1089265

TRI26
Tripartite motif-containing protein 26

1

3

High-throughput

0.541

High

1382521

TRI52
E3 ubiquitin-protein ligase TRIM52

1

6

High-throughput

0.541

High

1390290

TRI11
E3 ubiquitin-protein ligase TRIM11

1

2

High-throughput

0.541

High

1029147

E2F1
Transcription factor E2F1

1

0

Small-scale

0.537

High

1159357

FRDA
Frataxin, mitochondrial

1

0

Small-scale

0.537

High

1315651

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.537

High

1414946

ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2

1

0

Small-scale

0.537

High

931207

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

1

High-throughput

0.536

High

954738

SEM1
26S proteasome complex subunit SEM1

1

1

Small-scale

0.536

High

1161208

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

1339334

BBS1
BBSome complex member BBS1

1

1

High-throughput

0.536

High

1386348

FAF2
FAS-associated factor 2

1

10

High-throughput

0.536

High

1407451

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.518

High

608344

EGLN
Endoglin

1

0

High-throughput

0.513

High

1332679

CAST3
Putative protein CASTOR3P

1

0

High-throughput

0.513

High

920251

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.508

High

1098837

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

2

Small-scale

0.501

High

1060030

SCN1B
Sodium channel regulatory subunit beta-1

1

1

High-throughput

0.489

High

1414939

GDE1
Glycerophosphodiester phosphodiesterase 1

1

1

High-throughput

0.489

High

326838

SPN1
Snurportin-1

1

0

High-throughput

0.486

High

352728

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

777630

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.486

High

995236

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

288498

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

High-throughput

0.481

High

1387328

OTUB2
Ubiquitin thioesterase OTUB2

1

4

High-throughput

0.481

High

1414951

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

High-throughput

0.481

High

160598

IRS4
Insulin receptor substrate 4

1

1

High-throughput

0.479

High

220979

XPOT
Exportin-T

1

2

High-throughput

0.479

High

260397

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

302628

RNF8
E3 ubiquitin-protein ligase RNF8

1

7

Small-scale

0.479

High

323775

AP2A2
AP-2 complex subunit alpha-2

1

4

High-throughput

0.479

High

414534

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

460626

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.479

High

487704

PARP1
Poly [ADP-ribose] polymerase 1

1

2

Small-scale

0.479

High

755779

MCM4
DNA replication licensing factor MCM4

1

2

High-throughput

0.479

High

773620

COPB2
Coatomer subunit beta'

1

4

High-throughput

0.479

High

846665

MSH2
DNA mismatch repair protein Msh2

1

1

High-throughput

0.479

High

868244

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.479

High

887717

PSB2
Proteasome subunit beta type-2

1

7

Small-scale

0.479

High

888297

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

913390

MSH6
DNA mismatch repair protein Msh6

1

1

High-throughput

0.479

High

921766

COPB
Coatomer subunit beta

1

3

High-throughput

0.479

High

922013

COPA
Coatomer subunit alpha

1

4

High-throughput

0.479

High

927121

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

935080

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

951841

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

1005716

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

1

High-throughput

0.479

High

1046412

UBXN1
UBX domain-containing protein 1

1

7

Small-scale

0.479

High

1094970

TRAF3
TNF receptor-associated factor 3

1

6

Small-scale

0.479

High

1102246

ATM
Serine-protein kinase ATM

1

4

Small-scale

0.479

High

1109500

ATR
Serine/threonine-protein kinase ATR

1

4

Small-scale

0.479

High

1114176

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1121862

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

4

High-throughput

0.479

High

1130171

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.479

High

1217909

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

2

High-throughput

0.479

High

1259146

LARP4
La-related protein 4

1

1

High-throughput

0.479

High

1280463

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1323449

NUP93
Nuclear pore complex protein Nup93

1

1

High-throughput

0.479

High

1371650

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.479

High

1389447

CHFR
E3 ubiquitin-protein ligase CHFR

1

1

Small-scale

0.479

High

1407234

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

4

High-throughput

0.479

High

1414933

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

1

High-throughput

0.479

High

1414935

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1414936

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1414941

WRP73
WD repeat-containing protein WRAP73

1

2

High-throughput

0.479

High

1414944

MYO6
Unconventional myosin-VI

1

5

High-throughput

0.479

High

1414945

FAF1
FAS-associated factor 1

1

10

High-throughput

0.479

High

1414947

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

1414952

TRAF6
TNF receptor-associated factor 6

1

7

High-throughput

0.479

High

1414953

COPG1
Coatomer subunit gamma-1

1

3

High-throughput

0.479

High

1234738

CENPP
Centromere protein P

1

0

High-throughput

0.460

High

1363756

PSMF1
Proteasome inhibitor PI31 subunit

1

0

High-throughput

0.460

High

1411803

MIEN1
Migration and invasion enhancer 1

1

0

High-throughput

0.460

High

262126

NBN
Nibrin

1

0

Small-scale

0.458

High

294272

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

425014

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.458

High

663445

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

High-throughput

0.458

High

703045

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

772629

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.458

High

838780

MTREX
Exosome RNA helicase MTR4

1

0

High-throughput

0.458

High

892933

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

1032534

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.458

High

1054323

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.458

High

1135798

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1137140

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.458

High

1383837

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.458

High

1414937

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.458

High

1414949

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.458

High

598190

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

High-throughput

0.437

High

1249175

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

1210304

MF14B
Hippocampus abundant transcript-like protein 1

1

2

High-throughput

0.407

High

1240949

S27A4
Long-chain fatty acid transport protein 4

1

3

High-throughput

0.407

High

1273798

NIPA1
Magnesium transporter NIPA1

1

1

High-throughput

0.407

High

1288447

SO6A1
Solute carrier organic anion transporter family member 6A1

1

3

High-throughput

0.407

High

1309403

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

4

High-throughput

0.407

High

1381025

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.407

High

1414948

S35A3
UDP-N-acetylglucosamine transporter

1

1

High-throughput

0.407

High

1129299

BLTP2
Bridge-like lipid transfer protein family member 2

3

0

High-throughput

0.347

High

1164540

MIC60
MICOS complex subunit MIC60

2

0

Small-scale

0.305

High

1210049

CF136
Uncharacterized protein C6orf136

1

0

High-throughput

0.279

Low

692478

G0S2
G0/G1 switch protein 2

1

0

Small-scale

0.261

Low

327697

UBL3
Ubiquitin-like protein 3

1

0

High-throughput

0.251

Low

165642

SCAM3
Secretory carrier-associated membrane protein 3

1

0

Small-scale

0.249

Low

1347996

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low

1414938

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

870409

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

0

High-throughput

0.232

Low

1208671

NTCP5
Sodium/bile acid cotransporter 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025