Protein: RNF13
E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13)

Gene: RNF13
Organism: Homo sapiens
Interactions: 79
UniProt ID: O43567

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005637 - nuclear inner membrane
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

220516

RN167
E3 ubiquitin-protein ligase RNF167

2

15

High-throughput

0.811

High

220481

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.800

High

220488

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.800

High

220490

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.800

High

220454

RNF13
E3 ubiquitin-protein ligase RNF13

2

14

Small-scale

0.778

High

158736

AP3D1
AP-3 complex subunit delta-1

5

11

Small-scale

0.721

High

220512

AP3S1
AP-3 complex subunit sigma-1

4

4

Small-scale

0.703

High

220484

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

220489

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

220513

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

220521

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

125090

LEG9
Galectin-9

3

4

Small-scale

0.674

High

127224

LEG8
Galectin-8

3

4

High-throughput

0.667

High

220473

COT2
COUP transcription factor 2

3

4

High-throughput

0.667

High

220476

TYK2
Non-receptor tyrosine-protein kinase TYK2

3

11

High-throughput

0.667

High

220487

AP3S2
AP-3 complex subunit sigma-2

3

4

High-throughput

0.667

High

220518

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

3

High-throughput

0.667

High

220520

CLC11
C-type lectin domain family 11 member A

3

2

High-throughput

0.667

High

220482

CLCN7
H(+)/Cl(-) exchange transporter 7

3

0

High-throughput

0.638

High

220485

AP1S2
AP-1 complex subunit sigma-2

2

4

High-throughput

0.628

High

220468

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

High-throughput

0.618

High

220508

RN149
E3 ubiquitin-protein ligase RNF149

1

16

High-throughput

0.618

High

220466

CD63
CD63 antigen

2

7

High-throughput

0.611

High

220469

COT1
COUP transcription factor 1

2

4

High-throughput

0.611

High

220506

STX12
Syntaxin-12

2

4

High-throughput

0.611

High

220457

TSN3
Tetraspanin-3

3

7

High-throughput

0.609

High

220455

DCX
Neuronal migration protein doublecortin

2

0

High-throughput

0.602

High

220524

HDGR3
Hepatoma-derived growth factor-related protein 3

2

0

High-throughput

0.585

High

220477

VIPR1
Vasoactive intestinal polypeptide receptor 1

2

1

High-throughput

0.574

High

220517

MANS1
MANSC domain-containing protein 1

2

2

High-throughput

0.574

High

220497

TRI29
Tripartite motif-containing protein 29

1

2

Small-scale

0.561

High

220460

SNAPN
SNARE-associated protein Snapin

1

0

Small-scale

0.554

High

212359

SPIT2
Kunitz-type protease inhibitor 2

1

4

High-throughput

0.536

High

220465

PGK2
Phosphoglycerate kinase 2

1

2

High-throughput

0.536

High

220467

LEG1
Galectin-1

1

4

High-throughput

0.536

High

220478

STA5A
Signal transducer and activator of transcription 5A

1

2

High-throughput

0.536

High

220480

NEST
Nestin

1

17

High-throughput

0.536

High

220483

VAMP7
Vesicle-associated membrane protein 7

1

5

High-throughput

0.536

High

220498

STAR3
StAR-related lipid transfer protein 3

1

1

High-throughput

0.536

High

220499

SPCS2
Signal peptidase complex subunit 2

1

3

High-throughput

0.536

High

220501

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

9

High-throughput

0.536

High

220515

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

1

High-throughput

0.536

High

220522

DHRS7
Dehydrogenase/reductase SDR family member 7

1

10

High-throughput

0.536

High

220523

TMED5
Transmembrane emp24 domain-containing protein 5

1

7

High-throughput

0.536

High

163016

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.513

High

220474

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

220491

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

0

High-throughput

0.513

High

220504

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.513

High

220509

CCNY
Cyclin-Y

1

0

High-throughput

0.513

High

220459

AP1G2
AP-1 complex subunit gamma-like 2

1

8

High-throughput

0.489

High

220494

NKG2E
NKG2-E type II integral membrane protein

1

9

High-throughput

0.489

High

220511

HPSE2
Inactive heparanase-2

1

1

High-throughput

0.489

High

137300

ELL2
RNA polymerase II elongation factor ELL2

1

4

High-throughput

0.479

High

178109

NPC1
NPC intracellular cholesterol transporter 1

1

10

High-throughput

0.479

High

220456

AP1G1
AP-1 complex subunit gamma-1

1

8

Small-scale

0.479

High

220458

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

3

Small-scale

0.479

High

220462

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

220463

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

220493

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

2

Small-scale

0.479

High

220495

AHNK
Neuroblast differentiation-associated protein AHNAK

1

4

Small-scale

0.479

High

220496

SQSTM
Sequestosome-1

1

3

Small-scale

0.479

High

220503

FA83H
Protein FAM83H

1

1

Small-scale

0.479

High

220519

SRRM2
Serine/arginine repetitive matrix protein 2

1

3

Small-scale

0.479

High

220461

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

Small-scale

0.458

High

220464

PPB1
Alkaline phosphatase, placental type

1

0

Small-scale

0.458

High

220492

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

220500

ZNHI3
Zinc finger HIT domain-containing protein 3

1

0

Small-scale

0.458

High

220470

LEG3
Galectin-3

1

4

High-throughput

0.445

High

220471

LMNB1
Lamin-B1

1

7

Small-scale

0.445

High

220486

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

7

High-throughput

0.445

High

220502

MFS12
Major facilitator superfamily domain-containing protein 12

1

1

High-throughput

0.445

High

220510

PHIP
PH-interacting protein

1

3

High-throughput

0.437

High

220472

S1PR1
Sphingosine 1-phosphate receptor 1

1

0

High-throughput

0.426

High

220507

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.426

High

220479

EAA1
Excitatory amino acid transporter 1

1

2

High-throughput

0.407

High

220505

SL9B2
Sodium/hydrogen exchanger 9B2

1

4

High-throughput

0.407

High

220514

PEBP4
Phosphatidylethanolamine-binding protein 4

1

0

High-throughput

0.249

Low

220475

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025