HitPredict

Interactor 1: PCGF5 (Q86SE9)
Polycomb group RING finger protein 5 (RING finger protein 159)
Gene: PCGF5

Interactor 2: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	24981860, 22493164
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 256 Hs			1 259
+	Hs
		718150 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00
+	Hs
		717977 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		717488 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		718406 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		1108511 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Hs
		717489 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		717887 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Hs
		1197588 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		1197566 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		PCGF5_HUMAN (30-257): 3.38e-44: 151: 29.41
+	Mm
		1112809 PCGF5_MOUSE (1-256): 2.03e-64: 203: 96.09		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Hs
		718164 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		1197582 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		718129 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Dr
		1186371 BMI1B_DANRE (1-230): 1.36e-57: 188: 28.69		RING2_DANRE (24-259): 5.59e-38: 137: 16.56
+	Hs
		584870 RO52_HUMAN (3-242): 5.86e-56: 187: 13.79		RO52_HUMAN (32-226): 9.58e-36: 134: 18.61
+	Hs
		987986 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Hs
		717765 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		TRI26_HUMAN (32-223): 6.79e-32: 124: 19.90
+	Hs
		717742 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Hs
		282521 RO52_HUMAN (3-242): 5.86e-56: 187: 13.79		RNF8_HUMAN (24-130): 3e-10: 61.7: 28.04