HitPredict

Interactor 1: ISCA2 (Q86U28)
Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1)
Gene: ISCA2

Interactor 2: ISCA1 (Q9BUE6)
Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA) (hIscA)
Gene: ISCA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	33961781, 25347204
Identification Methods	affinity chromatography technology, nuclear magnetic resonance, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Fe-S_biosyn~Fe-S_biosyn
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0005829 - cytosol GO:0016226 - iron-sulfur cluster assembly GO:0051537 - 2 iron, 2 sulfur cluster binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 154 Hs			1 129
+	Hs
		1198944 ISCA2_HUMAN (1-154): 1.52e-69: 208: 100.00		ISCA2_HUMAN (1-129): 2.18e-53: 166: 25.39
+	Sp
		945052 ISA1_SCHPO (17-151): 1.62e-45: 148: 24.46		ISA1_SCHPO (7-128): 3.96e-50: 159: 38.21
+	Ec
		940341 SUFA_ECOLI (48-152): 4.83e-41: 135: 32.41		SUFA_ECOLI (23-129): 3.08e-47: 149: 38.32
+	Ss
		937173 Y1417_SYNY3 (39-152): 1.45e-41: 136: 32.77		Y1417_SYNY3 (24-129): 2.18e-46: 147: 30.56
+	Ec
		465794 ISCA_ECOLI (49-152): 8.02e-41: 134: 37.38		ISCA_ECOLI (24-129): 1.09e-46: 147: 37.74
+	Sc
		992219 ISA1_YEAST (50-152): 7.84e-43: 144: 29.52		ISA2_YEAST (25-129): 3.55e-33: 116: 23.62