Protein: HFE
Hereditary hemochromatosis protein (HLA-H)

Gene: HFE
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q30201

Gene Ontology (top 5):
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002476 - antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002486 - antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0002725 - negative regulation of T cell cytokine production
GO:0005102 - signaling receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

364296

TFR1
Transferrin receptor protein 1

7

4

Small-scale

0.961

High

901877

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

4

18

Small-scale

0.900

High

182272

TPSN
Tapasin

1

15

High-throughput

0.691

High

338501

EGFR
Epidermal growth factor receptor

1

11

High-throughput

0.691

High

382598

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

20

High-throughput

0.691

High

410566

CD1A
T-cell surface glycoprotein CD1a

1

17

High-throughput

0.691

High

439333

CATG
Cathepsin G

1

6

High-throughput

0.691

High

488245

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

16

High-throughput

0.691

High

789676

LIFR
Leukemia inhibitory factor receptor

1

5

High-throughput

0.691

High

879401

FCGRN
IgG receptor FcRn large subunit p51

1

16

High-throughput

0.691

High

945198

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

20

High-throughput

0.691

High

1069920

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

6

High-throughput

0.691

High

1103644

RN128
E3 ubiquitin-protein ligase RNF128

1

8

High-throughput

0.691

High

1103649

BT2A2
Butyrophilin subfamily 2 member A2

1

7

High-throughput

0.691

High

1103651

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

6

High-throughput

0.691

High

1103653

HMR1
Major histocompatibility complex class I-related gene protein

1

17

High-throughput

0.691

High

1103667

RN167
E3 ubiquitin-protein ligase RNF167

1

7

High-throughput

0.691

High

1103672

NECT3
Nectin-3

1

3

High-throughput

0.691

High

532966

PRG2
Bone marrow proteoglycan

1

11

High-throughput

0.618

High

1103639

RN149
E3 ubiquitin-protein ligase RNF149

1

8

High-throughput

0.618

High

1103646

NEUFC
Neuferricin

1

3

High-throughput

0.618

High

1103678

FPRP
Prostaglandin F2 receptor negative regulator

1

1

High-throughput

0.618

High

1103684

TFR2
Transferrin receptor protein 2

1

3

Small-scale

0.618

High

1103632

LYZL1
Lysozyme-like protein 1

1

0

High-throughput

0.578

High

152295

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

15

High-throughput

0.536

High

225302

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

1

1

High-throughput

0.536

High

253469

PLXA2
Plexin-A2

1

8

High-throughput

0.536

High

318381

ECEL1
Endothelin-converting enzyme-like 1

1

5

High-throughput

0.536

High

514392

PSPC
Surfactant protein C

1

5

High-throughput

0.536

High

530246

ICAM2
Intercellular adhesion molecule 2

1

1

High-throughput

0.536

High

585606

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

1

1

High-throughput

0.536

High

613254

ITA6
Integrin alpha-6

1

2

High-throughput

0.536

High

816680

GLRB
Glycine receptor subunit beta

1

6

High-throughput

0.536

High

821491

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

1

High-throughput

0.536

High

1013925

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

5

High-throughput

0.536

High

1036624

SQSTM
Sequestosome-1

1

4

High-throughput

0.536

High

1048490

DAG1
Dystroglycan 1

1

1

High-throughput

0.536

High

1053504

GAS6
Growth arrest-specific protein 6

1

4

High-throughput

0.536

High

1059118

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.536

High

1079483

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

1

High-throughput

0.536

High

1088198

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

5

High-throughput

0.536

High

1103630

BRID5
BRICHOS domain-containing protein 5

1

5

High-throughput

0.536

High

1103641

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

1

13

High-throughput

0.536

High

1103642

DIK2A
Divergent protein kinase domain 2A

1

2

High-throughput

0.536

High

1103652

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

5

High-throughput

0.536

High

1103655

T106A
Transmembrane protein 106A

1

6

High-throughput

0.536

High

1103656

ASIC4
Acid-sensing ion channel 4

1

9

High-throughput

0.536

High

1103657

P121A
Nuclear envelope pore membrane protein POM 121

1

1

High-throughput

0.536

High

1103663

CNTP3
Contactin-associated protein-like 3

1

2

High-throughput

0.536

High

1103664

ABCA2
ATP-binding cassette sub-family A member 2

1

3

High-throughput

0.536

High

1103665

SEM6A
Semaphorin-6A

1

5

High-throughput

0.536

High

1103673

CNNM1
Metal transporter CNNM1

1

4

High-throughput

0.536

High

1103676

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

7

High-throughput

0.536

High

1103677

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

15

High-throughput

0.536

High

1103679

P2RX2
P2X purinoceptor 2

1

1

High-throughput

0.536

High

1103685

ENTP4
Ectonucleoside triphosphate diphosphohydrolase 4

1

4

High-throughput

0.536

High

1103686

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

6

High-throughput

0.536

High

1103687

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.536

High

1103688

LRP12
Low-density lipoprotein receptor-related protein 12

1

5

High-throughput

0.536

High

1103689

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

4

High-throughput

0.536

High

134472

PODXL
Podocalyxin

1

0

High-throughput

0.513

High

224448

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.513

High

297912

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.513

High

300671

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.513

High

319446

RPP29
Ribonuclease P protein subunit p29

1

0

High-throughput

0.513

High

436985

DAF
Complement decay-accelerating factor

1

0

High-throughput

0.513

High

919408

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

972099

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

1

0

High-throughput

0.513

High

1035081

TUSC3
Tumor suppressor candidate 3

1

0

High-throughput

0.513

High

1103631

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.513

High

1103634

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.513

High

1103636

TM219
Insulin-like growth factor-binding protein 3 receptor

1

0

High-throughput

0.513

High

1103638

TM199
Transmembrane protein 199

1

0

High-throughput

0.513

High

1103648

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.513

High

1103658

SENP5
Sentrin-specific protease 5

1

0

High-throughput

0.513

High

1103660

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.513

High

1103669

TAF9B
Transcription initiation factor TFIID subunit 9B

1

0

High-throughput

0.513

High

1103683

VANG2
Vang-like protein 2

1

0

High-throughput

0.513

High

1103650

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

High-throughput

0.493

High

197130

SIA8C
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

1

13

High-throughput

0.489

High

267768

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

2

High-throughput

0.489

High

314474

APOM
Apolipoprotein M

1

2

High-throughput

0.489

High

314552

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

1

5

High-throughput

0.489

High

331657

B3GT4
Beta-1,3-galactosyltransferase 4

1

6

High-throughput

0.489

High

603355

FUT4
Alpha-(1,3)-fucosyltransferase 4

1

2

High-throughput

0.489

High

946392

EREP3
Protein ENTREP3

1

1

High-throughput

0.489

High

1014786

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

13

High-throughput

0.489

High

1103627

UD3A2
UDP-glucuronosyltransferase 3A2

1

6

High-throughput

0.489

High

1103635

DYR2
Dihydrofolate reductase 2, mitochondrial

1

2

High-throughput

0.489

High

1103637

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

2

High-throughput

0.489

High

1103640

NETO2
Neuropilin and tolloid-like protein 2

1

6

High-throughput

0.489

High

1103643

PXYP1
2-phosphoxylose phosphatase 1

1

1

High-throughput

0.489

High

1103645

GPX8
Probable glutathione peroxidase 8

1

2

High-throughput

0.489

High

1103661

LMF2
Lipase maturation factor 2

1

2

High-throughput

0.489

High

1103666

SIA7D
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

1

13

High-throughput

0.489

High

1103670

S38AA
Solute carrier family 38 member 10

1

3

High-throughput

0.489

High

1103671

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.489

High

1103675

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

3

High-throughput

0.489

High

1103681

TM59L
Transmembrane protein 59-like

1

1

High-throughput

0.489

High

1103682

CCPG1
Cell cycle progression protein 1

1

2

High-throughput

0.489

High

1103691

POMT1
Protein O-mannosyl-transferase 1

1

2

High-throughput

0.489

High

205458

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

1103633

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

10

Small-scale

0.479

High

364558

TRFE
Serotransferrin

1

0

Small-scale

0.458

High

389464

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.279

Low

1103628

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.279

Low

1103629

TYW1B
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B

1

0

High-throughput

0.279

Low

1103647

THEM6
Protein THEM6

1

0

High-throughput

0.279

Low

1103654

NXPE3
NXPE family member 3

1

0

High-throughput

0.279

Low

1103659

TM87B
Transmembrane protein 87B

1

0

High-throughput

0.279

Low

1103662

CA043
Protein C1orf43

1

0

High-throughput

0.279

Low

1103668

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low

1103674

CHST7
Carbohydrate sulfotransferase 7

1

0

High-throughput

0.279

Low

1103680

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.279

Low

1103690

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024