HitPredict

Interactor 1: AP3B1 (O00203)
AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)
Gene: AP3B1

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	27424887, 24725412
Identification Methods	anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005794 - Golgi apparatus GO:0007040 - lysosome organization GO:0007283 - spermatogenesis
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1094 Hs			1 2527
+	Hs
		3344 A0A0S2Z5J4_HUMAN (1-1094): 0: 989: 100.00		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		72401 B3KXW5_HUMAN (16-830): 0: 579: 13.12		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		3574 A0A140VJE8_HUMAN (33-888): 9.35e-180: 552: 22.21		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1014027 AP1B1_HUMAN (33-725): 2.94e-176: 542: 25.56		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		302166 AP2A2_HUMAN (42-660): 3.11e-152: 479: 12.87		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		321525 AP2A1_HUMAN (42-648): 1.93e-154: 486: 14.02		M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38
+	Hs
		302135 AP2A2_HUMAN (42-660): 3.11e-152: 479: 12.87		M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38
+	At
		1352915 COPB2_ARATH (46-507): 5.35e-96: 329: 22.11		BRL2_ARATH (1470-1771): 1.68e-09: 65.8: 10.33