Protein: TLN2
Talin-2

Gene: TLN2
Organism: Homo sapiens
Interactions: 44
UniProt ID: Q9Y4G6

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0003779 - actin binding
GO:0005178 - integrin binding
GO:0005198 - structural molecule activity
GO:0005200 - structural constituent of cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1491344

TLN1
Talin-1

4

17

High-throughput

0.873

High

1214249

KANK4
KN motif and ankyrin repeat domain-containing protein 4

3

19

High-throughput

0.855

High

424110

ITB2
Integrin beta-2

1

20

Small-scale

0.747

High

362423

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.724

High

1434443

RGCC
Regulator of cell cycle RGCC

3

1

High-throughput

0.667

High

581393

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

612130

ITB5
Integrin beta-5

1

18

Small-scale

0.618

High

1462014

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

245819

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

9

Small-scale

0.561

High

530655

TAU
Microtubule-associated protein tau

2

14

High-throughput

0.552

High

876747

HSP13
Heat shock 70 kDa protein 13

1

13

High-throughput

0.541

High

992407

SKP1
S-phase kinase-associated protein 1

1

2

High-throughput

0.536

High

1347907

RIN3
Ras and Rab interactor 3

1

9

High-throughput

0.536

High

1361809

DGCR8
Microprocessor complex subunit DGCR8

1

2

High-throughput

0.536

High

1404542

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

1433146

CHM4B
Charged multivesicular body protein 4b

1

7

High-throughput

0.536

High

1451439

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

2

High-throughput

0.536

High

106914

APRIO
Alternative prion protein

2

8

High-throughput

0.533

High

390229

ALBU
Albumin

1

0

High-throughput

0.513

High

250910

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

9

High-throughput

0.489

High

598280

CL3L1
C-C motif chemokine 3-like 1

1

2

High-throughput

0.489

High

1120409

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

8

High-throughput

0.489

High

1389531

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

12

High-throughput

0.489

High

243389

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

409144

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

446096

ENOA
Alpha-enolase

1

5

High-throughput

0.479

High

718857

CCND2
G1/S-specific cyclin-D2

1

1

Small-scale

0.479

High

791872

SYUA
Alpha-synuclein

1

7

High-throughput

0.479

High

986835

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.479

High

1107372

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1156251

ZYX
Zyxin

1

14

High-throughput

0.479

High

1256246

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1459439

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

889533

CLK1
Dual specificity protein kinase CLK1

1

19

High-throughput

0.457

High

404969

PRIO
Major prion protein

1

4

High-throughput

0.445

High

935340

TERA
Transitional endoplasmic reticulum ATPase

1

11

High-throughput

0.445

High

370822

FOS
Protein c-Fos

1

4

High-throughput

0.437

High

954768

SEM1
26S proteasome complex subunit SEM1

1

1

Small-scale

0.437

High

1290858

ZCH18
Zinc finger CCCH domain-containing protein 18

1

15

High-throughput

0.437

High

1450985

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

7

High-throughput

0.437

High

1237990

Q6NSK7
RIN3 protein

1

6

High-throughput

0.417

High

1227772

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.407

High

1315496

K2013
Uncharacterized protein KIAA2013

2

0

High-throughput

0.305

High

1250902

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025