HitPredict

Interactor 1: STING (Q86WV6)
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)
Gene: STING1

Interactor 2: UBP20 (Q9Y2K6)
Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)
Gene: USP20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	27801882, 30814308
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm GO:0140374 - antiviral innate immune response
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 379 Hs			1 914
+	Mm
		1111067 STING_MOUSE (1-378): 0: 588: 69.05		UBP20_MOUSE (1-914): 0: 840: 92.47
+	Mm
		1111213 STING_MOUSE (1-378): 0: 588: 69.05		UBP33_MOUSE (1-914): 0: 791: 59.26
+	Hs
		1203599 STING_HUMAN (1-379): 0: 572: 100.00		UBP3_HUMAN (420-693): 7.77e-67: 234: 31.05
+	Hs
		1203593 STING_HUMAN (1-379): 0: 572: 100.00		UBP22_HUMAN (240-688): 4.25e-56: 204: 18.52
+	Mm
		1110600 STING_MOUSE (1-378): 0: 588: 69.05		UBP19_MOUSE (85-409): 1.04e-42: 171: 18.21
+	Hs
		271135 STING_HUMAN (1-379): 0: 572: 100.00		UBP2_HUMAN (96-271): 1.55e-47: 181: 27.22
+	Mm
		1111211 STING_MOUSE (1-378): 0: 588: 69.05		UBP15_MOUSE (132-247): 4.78e-18: 91.7: 41.80
+	Hs
		1173814 STING_HUMAN (1-379): 0: 572: 100.00		UBP49_HUMAN (107-294): 1.77e-21: 102: 19.37