HitPredict

Interactor 1: RHOD (O00212)
Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)
Gene: RHOD

Interactor 2: PLXA1 (Q9UIW2)
Plexin-A1 (Semaphorin receptor NOV)
Gene: PLXNA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	11784792, 31871319
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 210 Hs			1 1896
+	Hs
		1335381 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		925714 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		545690 RAC2_HUMAN (15-209): 1.06e-73: 222: 45.64		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		892670 RAC3_HUMAN (15-191): 1.93e-73: 222: 51.98		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		165255 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		120208 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165187 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165157 RHOQ_HUMAN (12-210): 7.44e-74: 223: 42.08		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165155 RAC2_HUMAN (15-209): 1.06e-73: 222: 45.64		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165179 RAC3_HUMAN (15-191): 1.93e-73: 222: 51.98		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165251 RHOJ_HUMAN (3-209): 1.65e-72: 220: 38.65		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Dm
		816387 RHO1_DROME (19-200): 2.84e-76: 229: 53.30		PLXB_DROME (45-1109): 0: 848: 27.10
+	Dm
		776907 RAC1_DROME (15-202): 4.22e-74: 223: 48.94		PLXB_DROME (45-1109): 0: 848: 27.10
+	Dm
		819748 RAC2_DROME (15-200): 3.29e-73: 221: 48.93		PLXB_DROME (45-1109): 0: 848: 27.10
+	Hs
		1245059 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		120548 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		925450 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		564678 RHOQ_HUMAN (12-210): 7.44e-74: 223: 42.08		SEM6A_HUMAN (6-549): 2.71e-119: 406: 16.36
+	Hs
		441478 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		MET_HUMAN (814-1212): 1.56e-103: 367: 25.80
+	Hs
		120220 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		PLXB1_HUMAN (558-875): 1.91e-12: 75.2: 18.58