HitPredict

Interactor 1: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Interactor 2: DOCK5 (Q9H7D0)
Dedicator of cytokinesis protein 5
Gene: DOCK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Hs			1 1870
+	Hs
		545622 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOCK5_HUMAN (1-1870): 0: 1989: 100.00
+	Hs
		545372 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		950991 RHOG_HUMAN (3-170): 1.68e-74: 238: 27.47		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		545535 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOCK2_HUMAN (1-1825): 0: 1845: 54.97
+	Dm
		776892 RAC1_DROME (3-180): 6.89e-80: 252: 25.52		Q8MQW7_DROME (683-1821): 0: 1050: 36.60
+	Hs
		545596 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOCK9_HUMAN (945-1640): 0: 706: 16.39
+	Hs
		892573 RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22		DOCK9_HUMAN (945-1640): 0: 706: 16.39
+	Mm
		101404 CDC42_MOUSE (3-172): 5.67e-77: 244: 25.54		F8VPN7_MOUSE (945-1679): 0: 706: 15.77
+	Hs
		894393 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		DOCK9_HUMAN (945-1640): 0: 706: 16.39
+	Hs
		1070378 RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70		DOCK9_HUMAN (945-1640): 0: 706: 16.39
+	Hs
		951301 RHOG_HUMAN (3-170): 1.68e-74: 238: 27.47		DOCK9_HUMAN (945-1640): 0: 706: 16.39
+	Hs
		545421 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		DOC11_HUMAN (945-1650): 0: 657: 15.01
+	Mm
		57052 CDC42_MOUSE (3-172): 5.67e-77: 244: 25.54		DOC11_MOUSE (945-1650): 0: 663: 15.01
+	Hs
		892410 RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22		DOC11_HUMAN (945-1650): 0: 657: 15.01
+	Hs
		894099 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		DOC11_HUMAN (945-1650): 0: 657: 15.01
+	Hs
		894298 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		DOC10_HUMAN (968-1676): 0: 642: 15.58
+	Mm
		892732 CDC42_MOUSE (3-172): 5.67e-77: 244: 25.54		DOC10_MOUSE (968-1677): 0: 635: 15.43
+	Hs
		894322 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		DOCK7_HUMAN (59-927): 2.15e-156: 533: 14.05
+	Hs
		1070346 RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70		DOCK7_HUMAN (59-927): 2.15e-156: 533: 14.05
+	Hs
		894226 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		DOCK8_HUMAN (753-942): 5.88e-24: 112: 10.40