HitPredict

Interactor 1: AMOL1 (Q8IY63)
Angiomotin-like protein 1
Gene: AMOTL1

Interactor 2: HECW2 (Q9P2P5)
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
Gene: HECW2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	27498087, 24163370
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 956 Hs			1 1572
+	Hs
		1350508 AMOL2_HUMAN (92-914): 4.21e-45: 177: 40.12		HECW2_HUMAN (1-1572): 0: 1176: 100.00
+	Hs
		1119083 AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18		HECW2_HUMAN (1-1572): 0: 1176: 100.00
+	Hs
		149380 CTRO_HUMAN (238-841): 1.53e-21: 103: 12.00		HECW2_HUMAN (1-1572): 0: 1176: 100.00
+	Hs
		724896 MYH9_HUMAN (226-951): 4.21e-24: 111: 9.29		HUWE1_HUMAN (1007-1571): 2.14e-157: 535: 31.55
+	Hs
		125569 AMOL1_HUMAN (1-956): 6.37e-156: 486: 100.00		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		1222263 AMOL1_HUMAN (1-956): 6.37e-156: 486: 100.00		NED4L_HUMAN (664-1033): 5.09e-15: 82.9: 15.47
+	Hs
		1222267 AMOL1_HUMAN (1-956): 6.37e-156: 486: 100.00		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		808183 AMOL1_HUMAN (1-956): 6.37e-156: 486: 100.00		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Hs
		125805 AMOL2_HUMAN (92-914): 4.21e-45: 177: 40.12		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		1327936 AMOL2_HUMAN (92-914): 4.21e-45: 177: 40.12		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		808328 AMOL2_HUMAN (92-914): 4.21e-45: 177: 40.12		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Hs
		125503 AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		1119034 AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18		NED4L_HUMAN (664-1033): 5.09e-15: 82.9: 15.47
+	Hs
		1119052 AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		808151 AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Hs
		1119026 AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37
+	Hs
		1035209 ROCK1_HUMAN (418-836): 1.93e-14: 80.1: 10.94		SMUF1_HUMAN (177-586): 4.19e-31: 134: 13.74
+	Hs
		551845 DESP_HUMAN (417-798): 5.65e-11: 69.3: 15.63		SMUF1_HUMAN (177-586): 4.19e-31: 134: 13.74
+	Hs
		1336100 DAPLE_HUMAN (438-697): 6.07e-09: 62.6: 25.98		SMUF1_HUMAN (177-586): 4.19e-31: 134: 13.74
+	Hs
		1078893 ITSN1_HUMAN (608-950): 3e-09: 63.5: 11.36		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37