HitPredict

Interactor 1: BMR1B (O00238)
Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)
Gene: BMPR1B

Interactor 2: GDF5 (P43026)
Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
Gene: GDF5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	9525338, 19229295, 16127465
Identification Methods	pull down, x-ray crystallography, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0005886 - plasma membrane GO:0030509 - BMP signaling pathway GO:0032332 - positive regulation of chondrocyte differentiation GO:0036122 - BMP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 502 Hs			1 501
+	Hs
		738309 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		GDF5_HUMAN (1-501): 0: 605: 100.00
+	Hs
		122281 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		BMP4_HUMAN (108-501): 3.13e-115: 347: 27.64
+	Hs
		122282 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59
+	Hs
		122280 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		BMP2_HUMAN (127-501): 2.08e-107: 327: 29.59
+	Hs
		122283 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		BMP6_HUMAN (94-500): 1.53e-103: 321: 25.24
+	Hs
		520110 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		BMP4_HUMAN (108-501): 3.13e-115: 347: 27.64
+	Dm
		429971 Q24326_DROME (6-502): 7.7e-140: 415: 47.98		DECA_DROME (73-501): 2.28e-107: 333: 27.33
+	Dm
		429972 Q7JQ36_DROME (1-499): 2.66e-138: 412: 41.60		DECA_DROME (73-501): 2.28e-107: 333: 27.33
+	Hs
		574186 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59
+	Hs
		122292 BMR1B_HUMAN (1-502): 2.91e-155: 453: 100.00		GDF6_HUMAN (123-501): 1.61e-92: 290: 45.56
+	Hs
		520071 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		BMP2_HUMAN (127-501): 2.08e-107: 327: 29.59
+	Hs
		602926 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		BMP6_HUMAN (94-500): 1.53e-103: 321: 25.24
+	Hs
		738359 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		GDF6_HUMAN (123-501): 1.61e-92: 290: 45.56
+	Dm
		646113 Q24326_DROME (6-502): 7.7e-140: 415: 47.98		60A_DROME (106-500): 1.07e-89: 283: 20.97
+	Hs
		439885 ACVR1_HUMAN (19-499): 1.01e-138: 411: 49.70		INHBA_HUMAN (99-500): 2.68e-85: 271: 18.55
+	Hs
		495651 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		TGFB3_HUMAN (131-500): 9.88e-84: 266: 19.59
+	Hs
		738518 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		TGFB2_HUMAN (126-500): 5.22e-83: 264: 20.10
+	Hs
		351286 BMR1A_HUMAN (8-502): 2.33e-139: 413: 71.63		TGFB1_HUMAN (134-500): 5.75e-78: 251: 19.15
+	Hs
		351287 TGFR1_HUMAN (31-502): 9.48e-139: 411: 53.14		TGFB1_HUMAN (134-500): 5.75e-78: 251: 19.15
+	Dm
		871199 Q7JQ36_DROME (1-499): 2.66e-138: 412: 41.60		SCW_DROME (154-500): 1.33e-76: 247: 20.92