HitPredict

Interactor 1: UB2J2 (Q8N2K1)
Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J2) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2)
Gene: UBE2J2

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22496338
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 259 Hs			1 903
+	Hs
		125575 UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1294888 UB2D4_HUMAN (12-156): 2.24e-67: 207: 24.16		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		919827 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1231677 UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		919860 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		125808 UB2D4_HUMAN (12-156): 2.24e-67: 207: 24.16		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125262 UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125335 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		919834 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		808052 UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808078 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		849353 UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		919765 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		919782 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		HACE1_HUMAN (376-897): 4.35e-154: 478: 30.61
+	Hs
		1176340 UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76
+	Hs
		919869 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		919867 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Hs
		919889 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34
+	Hs
		849351 UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76
+	Hs
		919762 UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76