HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	36931259, 21282530, 22078878
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019899 - enzyme binding GO:0051219 - phosphoprotein binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 560 Hs			1 246
+	Hs
		123219 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		123226 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		123184 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		123218 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		123242 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		123190 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Mm
		926802 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02
+	Mm
		935508 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		1433F_MOUSE (4-244): 8.67e-108: 312: 75.51