Protein: DX39A
ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49)

Gene: DX39A, DDX39A
Organism: Homo sapiens
Interactions: 195
UniProt ID: O00148

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0003729 - mRNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

123096

DX39B
Spliceosome RNA helicase DDX39B

9

17

Small-scale

0.967

High

123006

DX39A
ATP-dependent RNA helicase DDX39A

4

16

High-throughput

0.896

High

123080

SARNP
SAP domain-containing ribonucleoprotein

7

3

Small-scale

0.755

High

123157

FBXW7
F-box/WD repeat-containing protein 7

2

12

Small-scale

0.754

High

123196

CHTOP
Chromatin target of PRMT1 protein

6

2

High-throughput

0.728

High

123147

THOC2
THO complex subunit 2

1

14

High-throughput

0.691

High

123106

TERF2
Telomeric repeat-binding factor 2

3

1

High-throughput

0.672

High

123162

THOC1
THO complex subunit 1

3

3

Small-scale

0.662

High

123112

NCBP3
Nuclear cap-binding protein subunit 3

3

3

High-throughput

0.650

High

123018

EED
Polycomb protein EED

1

20

High-throughput

0.618

High

123057

RECQ1
ATP-dependent DNA helicase Q1

1

19

High-throughput

0.618

High

123085

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

10

High-throughput

0.618

High

123100

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

10

High-throughput

0.618

High

123130

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

123058

SOX2
Transcription factor SOX-2

2

13

High-throughput

0.611

High

123077

TBA4A
Tubulin alpha-4A chain

2

4

High-throughput

0.611

High

123185

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

2

3

High-throughput

0.611

High

123078

RNF4
E3 ubiquitin-protein ligase RNF4

2

4

High-throughput

0.606

High

123135

THOC4
THO complex subunit 4

2

20

Small-scale

0.595

High

123013

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

123094

CUL4A
Cullin-4A

2

18

High-throughput

0.584

High

123076

UBC9
SUMO-conjugating enzyme UBC9

2

10

High-throughput

0.584

High

123046

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

6

High-throughput

0.575

High

123055

IF4A3
Eukaryotic initiation factor 4A-III

1

19

High-throughput

0.575

High

123192

DDX41
Probable ATP-dependent RNA helicase DDX41

1

19

High-throughput

0.575

High

123066

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.573

High

123114

FGD3
FYVE, RhoGEF and PH domain-containing protein 3

2

4

High-throughput

0.571

High

123156

ESR2
Estrogen receptor beta

2

13

High-throughput

0.571

High

123128

FAT4
Protocadherin Fat 4

2

3

High-throughput

0.558

High

123150

FAT3
Protocadherin Fat 3

2

5

High-throughput

0.558

High

123121

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.553

High

123142

PLD6
Mitochondrial cardiolipin hydrolase

1

1

High-throughput

0.553

High

123195

HECD1
E3 ubiquitin-protein ligase HECTD1

1

15

High-throughput

0.553

High

123007

FOXE1
Forkhead box protein E1

1

10

High-throughput

0.536

High

123010

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

123011

FOXS1
Forkhead box protein S1

1

11

High-throughput

0.536

High

123019

FOXH1
Forkhead box protein H1

1

13

High-throughput

0.536

High

123036

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.536

High

123037

RU1C
U1 small nuclear ribonucleoprotein C

1

4

High-throughput

0.536

High

123040

TOP1
DNA topoisomerase 1

1

5

High-throughput

0.536

High

123041

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

4

High-throughput

0.536

High

123069

FOXG1
Forkhead box protein G1

1

12

High-throughput

0.536

High

123070

FOXA3
Hepatocyte nuclear factor 3-gamma

1

10

High-throughput

0.536

High

123071

FOXL2
Forkhead box protein L2

1

10

High-throughput

0.536

High

123079

SRPK2
SRSF protein kinase 2

1

17

High-throughput

0.536

High

123083

SSRP1
FACT complex subunit SSRP1

1

12

High-throughput

0.536

High

123086

FOXC1
Forkhead box protein C1

1

12

High-throughput

0.536

High

123087

FOXI1
Forkhead box protein I1

1

10

High-throughput

0.536

High

123088

FOXL1
Forkhead box protein L1

1

10

High-throughput

0.536

High

123091

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.536

High

123092

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.536

High

123095

THOC5
THO complex subunit 5

1

3

High-throughput

0.536

High

123102

FL2D
Pre-mRNA-splicing regulator WTAP

1

2

High-throughput

0.536

High

123105

SF3A1
Splicing factor 3A subunit 1

1

7

High-throughput

0.536

High

123109

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

14

High-throughput

0.536

High

123123

THOC7
THO complex subunit 7

1

4

High-throughput

0.536

High

123126

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

5

High-throughput

0.536

High

123129

FOXI2
Forkhead box protein I2

1

9

High-throughput

0.536

High

123134

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

5

High-throughput

0.536

High

123136

FOXP4
Forkhead box protein P4

1

10

High-throughput

0.536

High

123137

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

123161

RBM33
RNA-binding protein 33

1

12

High-throughput

0.536

High

123169

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

123171

FOXB1
Forkhead box protein B1

1

12

High-throughput

0.536

High

123179

FOXQ1
Forkhead box protein Q1

1

12

High-throughput

0.536

High

123193

AGO2
Protein argonaute-2

1

15

High-throughput

0.536

High

123194

AGO1
Protein argonaute-1

1

16

High-throughput

0.536

High

123012

PCDH7
Protocadherin-7

2

5

High-throughput

0.533

High

123188

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.529

High

123009

SOCS2
Suppressor of cytokine signaling 2

1

5

High-throughput

0.515

High

114537

H0YHG0
DnaJ homolog subfamily C member 14

1

5

High-throughput

0.515

High

123032

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.515

High

123056

HD
Huntingtin

1

1

High-throughput

0.515

High

123132

Q7KZS0
SUMO-conjugating enzyme UBC9

1

10

High-throughput

0.515

High

123107

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

123187

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.513

High

123082

FAK1
Focal adhesion kinase 1

1

6

High-throughput

0.508

High

123073

SUMO2
Small ubiquitin-related modifier 2

1

6

High-throughput

0.501

High

123152

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

16

High-throughput

0.481

High

123008

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

11

High-throughput

0.479

High

123014

GANP
Germinal-center associated nuclear protein

1

4

High-throughput

0.479

High

123015

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

123020

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

123022

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.479

High

123023

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

7

Small-scale

0.479

High

123024

HERC2
E3 ubiquitin-protein ligase HERC2

1

16

High-throughput

0.479

High

123025

SNAI1
Zinc finger protein SNAI1

1

5

High-throughput

0.479

High

123027

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

123028

RASK
GTPase KRas

1

3

High-throughput

0.479

High

123030

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.479

High

123031

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

123033

ISG15
Ubiquitin-like protein ISG15

1

10

High-throughput

0.479

High

123038

PARP1
Poly [ADP-ribose] polymerase 1

1

5

Small-scale

0.479

High

123039

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

123042

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

6

Small-scale

0.479

High

123043

VAV
Proto-oncogene vav

1

9

High-throughput

0.479

High

123044

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

123045

CEBPB
CCAAT/enhancer-binding protein beta

1

12

High-throughput

0.479

High

123048

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

123049

UFO
Tyrosine-protein kinase receptor UFO

1

3

High-throughput

0.479

High

123051

PHB1
Prohibitin 1

1

6

High-throughput

0.479

High

123052

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

123053

VGFR3
Vascular endothelial growth factor receptor 3

1

1

High-throughput

0.479

High

123054

BRCA1
Breast cancer type 1 susceptibility protein

1

15

High-throughput

0.479

High

123059

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

123061

RBP2
E3 SUMO-protein ligase RanBP2

1

7

Small-scale

0.479

High

123062

CDK9
Cyclin-dependent kinase 9

1

11

High-throughput

0.479

High

123063

MECP2
Methyl-CpG-binding protein 2

1

10

High-throughput

0.479

High

123064

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.479

High

123065

ATX3
Ataxin-3

1

1

Small-scale

0.479

High

123067

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

6

High-throughput

0.479

High

123074

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

123075

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.479

High

123089

NFX1
Transcriptional repressor NF-X1

1

6

High-throughput

0.479

High

123090

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.479

High

123093

CUL3
Cullin-3

1

18

High-throughput

0.479

High

123098

RBM39
RNA-binding protein 39

1

16

High-throughput

0.479

High

123101

RHG19
Rho GTPase-activating protein 19

1

3

High-throughput

0.479

High

123103

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

20

High-throughput

0.479

High

123104

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.479

High

123108

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

123110

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

High-throughput

0.479

High

123111

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

123113

PKHG4
Puratrophin-1

1

5

High-throughput

0.479

High

123118

ARM12
Armadillo repeat-containing protein 12

1

1

Small-scale

0.479

High

123120

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

123122

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

123131

TBA1A
Tubulin alpha-1A chain

1

4

High-throughput

0.479

High

123133

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

123138

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

7

High-throughput

0.479

High

123139

CUL9
Cullin-9

1

11

Small-scale

0.479

High

123144

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

123145

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

123146

WDR19
WD repeat-containing protein 19

1

14

High-throughput

0.479

High

123151

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

123153

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

3

High-throughput

0.479

High

123154

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

15

High-throughput

0.479

High

123158

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

123159

OPTN
Optineurin

1

12

High-throughput

0.479

High

123164

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

123167

CI072
Guanine nucleotide exchange factor C9orf72

1

5

High-throughput

0.479

High

123168

CIC
Protein capicua homolog

1

14

High-throughput

0.479

High

123170

NECD
Necdin

1

6

High-throughput

0.479

High

123172

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.479

High

123174

OVOL2
Transcription factor Ovo-like 2

1

4

Small-scale

0.479

High

123175

FACD2
Fanconi anemia group D2 protein

1

9

High-throughput

0.479

High

123177

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.479

High

123178

API5
Apoptosis inhibitor 5

1

3

High-throughput

0.479

High

123180

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

2

High-throughput

0.479

High

123181

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

123183

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

123184

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

14

High-throughput

0.479

High

123186

FBX6
F-box only protein 6

1

5

High-throughput

0.479

High

123189

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

3

High-throughput

0.479

High

123190

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

123191

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

123197

TRRAP
Transformation/transcription domain-associated protein

1

5

High-throughput

0.479

High

123084

MN1
Transcriptional activator MN1

1

0

Small-scale

0.458

High

123140

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.458

High

123165

MAEL
Protein maelstrom homolog

1

0

Small-scale

0.458

High

123182

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

123016

GSDME
Gasdermin-E

1

1

High-throughput

0.445

High

123029

ANGI
Angiogenin

1

1

High-throughput

0.445

High

123034

JUN
Transcription factor Jun

1

13

High-throughput

0.445

High

123035

HEPS
Serine protease hepsin

1

1

High-throughput

0.445

High

123050

1433S
14-3-3 protein sigma

1

20

High-throughput

0.445

High

123068

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

123099

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

5

High-throughput

0.445

High

123115

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

123141

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.445

High

123143

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.445

High

123163

SYMM
Methionine--tRNA ligase, mitochondrial

1

1

High-throughput

0.445

High

123017

NIPS2
Protein NipSnap homolog 2

1

3

High-throughput

0.437

High

123026

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

123097

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

123116

FREM2
FRAS1-related extracellular matrix protein 2

1

4

High-throughput

0.437

High

123119

OTUD1
OTU domain-containing protein 1

1

3

High-throughput

0.437

High

123125

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

123148

DPTOR
DEP domain-containing mTOR-interacting protein

1

1

Small-scale

0.437

High

123166

SNX27
Sorting nexin-27

1

2

High-throughput

0.437

High

123176

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

6

High-throughput

0.437

High

123127

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

0

Small-scale

0.426

High

123155

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

123060

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.408

High

136

A0A024R6X4
PLEKHG4

1

5

High-throughput

0.407

High

123160

Q96D37
VAV1 protein

1

9

High-throughput

0.407

High

123173

TM2D3
TM2 domain-containing protein 3

2

0

High-throughput

0.318

High

123047

SAT1
Diamine acetyltransferase 1

1

0

High-throughput

0.299

High

123117

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.279

Low

123149

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.279

Low

123021

WFS1
Wolframin

1

0

High-throughput

0.268

Low

123072

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.249

Low

123081

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low

123124

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025