HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: ERCC6 (Q03468)
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
Gene: ERCC6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	21282530
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	Chromo~SNF2-rel_dom
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 1493
+	Hs
		976500 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		ERCC6_HUMAN (1-1493): 0: 1168: 100.00
+	Hs
		316016 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		ERCC6_HUMAN (1-1493): 0: 1168: 100.00
+	Hs
		123332 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		CHD7_HUMAN (3-1479): 0: 774: 17.81
+	Hs
		123245 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Hs
		1027145 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD5_HUMAN (300-1446): 0: 783: 19.15
+	Hs
		1027026 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD9_HUMAN (3-1492): 0: 774: 18.73
+	Hs
		1027300 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD7_HUMAN (3-1479): 0: 774: 17.81
+	Hs
		1027001 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		1018451 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Mm
		1161080 Q9DCC5_MOUSE (9-163): 8.8e-44: 155: 21.94		CHD4_MOUSE (303-1460): 0: 752: 18.67
+	Hs
		800360 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Hs
		1027277 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD8_HUMAN (2-1474): 0: 725: 16.46
+	Hs
		316054 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		ER6L2_HUMAN (493-1303): 0: 651: 27.38
+	Hs
		847118 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		SMCA4_HUMAN (228-1324): 0: 677: 19.90
+	Hs
		658667 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SMCA1_HUMAN (369-1372): 0: 700: 20.58
+	Hs
		229384 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SMCA5_HUMAN (368-1383): 0: 698: 20.75
+	Hs
		846954 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SMCA4_HUMAN (228-1324): 0: 677: 19.90
+	Hs
		800320 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		SMCA4_HUMAN (228-1324): 0: 677: 19.90
+	Hs
		800319 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		SMCA2_HUMAN (228-1247): 0: 660: 19.72
+	Hs
		163601 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BTAF1_HUMAN (490-1019): 9.59e-80: 293: 35.50