Interactor 1: PRP8 (Q6P2Q9)
Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)
Gene: PRPF8
Interactor 2: SNR40 (Q96DI7)
U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57)
Gene: SNRNP40
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.982 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26186194, 28514442, 17353931, 33961781, 9774689, 35271311, 37689310, 16723661, 28515276, 34079125, 35235311, 31839598, 40437099 |
| Identification Methods | affinity chromatography technology, pull down, proximity labelling technology, two hybrid, far western blotting, cross-linking study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PRO8NT~WD40, PROCN~WD40, PRP8_domainIV~WD40 |
| Common GO terms | GO:0000375 - RNA splicing, via transesterification reactions GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 6 others more... |
| Homologous interactions | 4 |
Homologous interactions
Color coding for hit scores 
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Last updated: 11Aug2025
