HitPredict

Interactor 1: PHC3 (Q8NDX5)
Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)
Gene: PHC3

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	24457600, 26496610, 27705803, 24981860, 22325352
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 983 Hs			1 336
+	Mm
		1208513 PHC3_MOUSE (30-983): 1.26e-78: 278: 93.61		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Hs
		987993 PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		1292152 SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1242732 PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		718028 PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718412 PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		1108519 PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00		PCGF3_HUMAN (36-334): 3.56e-44: 153: 18.15
+	Hs
		1242734 PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		1197572 PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00		PCGF5_HUMAN (34-334): 1.89e-39: 141: 15.24
+	Mm
		639476 PHC3_MOUSE (30-983): 1.26e-78: 278: 93.61		BMI1_MOUSE (34-332): 1.69e-44: 156: 15.23
+	Mm
		620790 PHC3_MOUSE (30-983): 1.26e-78: 278: 93.61		PCGF2_MOUSE (34-332): 2.29e-41: 149: 15.56
+	Hs
		988007 SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		554277 MUC1_HUMAN (2-764): 1.79e-44: 177: 11.56		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		1292153 SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		718098 SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718418 SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		1108531 SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83		PCGF3_HUMAN (36-334): 3.56e-44: 153: 18.15
+	Hs
		717684 PHC1_HUMAN (33-983): 9.51e-36: 148: 23.90		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718390 PHC1_HUMAN (33-983): 9.51e-36: 148: 23.90		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		1197578 SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83		PCGF5_HUMAN (34-334): 1.89e-39: 141: 15.24