Protein: NANOG
Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog)

Gene: NANOG
Organism: Homo sapiens
Interactions: 239
UniProt ID: Q9H9S0

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1437234

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

4

2

Small-scale

0.715

High

227670

SPOP
Speckle-type POZ protein

4

2

Small-scale

0.705

High

1410988

RHXF2
Rhox homeobox family member 2

1

19

High-throughput

0.698

High

587221

ITF2
Transcription factor 4

1

4

High-throughput

0.618

High

693367

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

8

Small-scale

0.618

High

733273

OTX2
Homeobox protein OTX2

1

19

High-throughput

0.618

High

1437213

NANOG
Homeobox protein NANOG

1

16

Small-scale

0.618

High

1437241

SATB2
DNA-binding protein SATB2

1

12

High-throughput

0.618

High

1371540

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

9

Small-scale

0.584

High

1437231

SALL4
Sal-like protein 4

2

19

Small-scale

0.584

High

1437246

ZN281
Zinc finger protein 281

2

13

Small-scale

0.584

High

578546

BRAF
Serine/threonine-protein kinase B-raf

1

5

Small-scale

0.561

High

992967

RACK1
Small ribosomal subunit protein RACK1

1

9

Small-scale

0.561

High

1437250

TRRAP
Transformation/transcription domain-associated protein

1

2

Small-scale

0.561

High

1372197

MED12
Mediator of RNA polymerase II transcription subunit 12

1

20

Small-scale

0.552

High

1412818

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.536

High

1035023

KPCE
Protein kinase C epsilon type

1

5

Small-scale

0.501

High

1372085

RBPMS
RNA-binding protein with multiple splicing

1

4

High-throughput

0.481

High

144319

ACACB
Acetyl-CoA carboxylase 2

1

2

High-throughput

0.479

High

166568

BACH1
Transcription regulator protein BACH1

1

8

Small-scale

0.479

High

172222

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

8

High-throughput

0.479

High

174402

ZN609
Zinc finger protein 609

1

20

High-throughput

0.479

High

180929

TIF1A
Transcription intermediary factor 1-alpha

1

14

High-throughput

0.479

High

189282

IPO8
Importin-8

1

2

High-throughput

0.479

High

249349

ZIC3
Zinc finger protein ZIC 3

1

9

High-throughput

0.479

High

258472

EDF1
Endothelial differentiation-related factor 1

1

2

High-throughput

0.479

High

261445

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

16

High-throughput

0.479

High

316996

MTA2
Metastasis-associated protein MTA2

1

20

High-throughput

0.479

High

336238

ZIC2
Zinc finger protein ZIC 2

1

11

High-throughput

0.479

High

352247

MBD3
Methyl-CpG-binding domain protein 3

1

3

High-throughput

0.479

High

401504

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

Small-scale

0.479

High

405624

HRG
Histidine-rich glycoprotein

1

9

High-throughput

0.479

High

457709

TBB5
Tubulin beta chain

1

4

High-throughput

0.479

High

510060

ZN865
Zinc finger protein 865

1

2

High-throughput

0.479

High

537928

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

559502

XRCC5
X-ray repair cross-complementing protein 5

1

8

High-throughput

0.479

High

574476

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.479

High

601864

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.479

High

623547

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.479

High

624526

WT1
Wilms tumor protein

1

9

High-throughput

0.479

High

703382

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

20

High-throughput

0.479

High

721068

CLIP1
CAP-Gly domain-containing linker protein 1

1

4

High-throughput

0.479

High

726803

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

4

High-throughput

0.479

High

765899

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.479

High

766121

PCGF2
Polycomb group RING finger protein 2

1

20

High-throughput

0.479

High

801535

HSPA9
Stress-70 protein, mitochondrial

1

5

High-throughput

0.479

High

841256

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.479

High

872756

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

883947

CENPF
Centromere protein F

1

8

High-throughput

0.479

High

888332

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

907651

ZN157
Zinc finger protein 157

1

4

High-throughput

0.479

High

931711

RD23B
UV excision repair protein RAD23 homolog B

1

5

High-throughput

0.479

High

938807

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

5

High-throughput

0.479

High

998033

CSK21
Casein kinase II subunit alpha

1

11

High-throughput

0.479

High

1006877

PHC1
Polyhomeotic-like protein 1

1

19

High-throughput

0.479

High

1029040

TIAR
Nucleolysin TIAR

1

4

High-throughput

0.479

High

1050823

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

1

High-throughput

0.479

High

1067726

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1089021

TP53B
TP53-binding protein 1

1

9

High-throughput

0.479

High

1089558

ILF2
Interleukin enhancer-binding factor 2

1

7

High-throughput

0.479

High

1098141

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.479

High

1098376

ERCC8
DNA excision repair protein ERCC-8

1

12

High-throughput

0.479

High

1098598

GPS2
G protein pathway suppressor 2

1

2

High-throughput

0.479

High

1102656

MTA1
Metastasis-associated protein MTA1

1

20

High-throughput

0.479

High

1106709

SMAD4
Mothers against decapentaplegic homolog 4

1

12

High-throughput

0.479

High

1108165

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

1109393

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

3

Small-scale

0.479

High

1114334

CUL3
Cullin-3

1

2

Small-scale

0.479

High

1115072

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

1117070

RUNX3
Runt-related transcription factor 3

1

3

High-throughput

0.479

High

1117925

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

6

Small-scale

0.479

High

1119997

CIRBP
Cold-inducible RNA-binding protein

1

6

High-throughput

0.479

High

1127766

HLTF
Helicase-like transcription factor

1

20

High-throughput

0.479

High

1132237

CBX2
Chromobox protein homolog 2

1

6

High-throughput

0.479

High

1137270

CND1
Condensin complex subunit 1

1

1

High-throughput

0.479

High

1137528

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1145533

RBBP5
Retinoblastoma-binding protein 5

1

10

High-throughput

0.479

High

1150254

TEAD2
Transcriptional enhancer factor TEF-4

1

3

High-throughput

0.479

High

1157938

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.479

High

1158084

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

1

High-throughput

0.479

High

1161403

HIF1A
Hypoxia-inducible factor 1-alpha

1

12

Small-scale

0.479

High

1168894

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

9

High-throughput

0.479

High

1199701

KLH22
Kelch-like protein 22

1

1

Small-scale

0.479

High

1206778

RRP12
RRP12-like protein

1

2

High-throughput

0.479

High

1208068

CYTSB
Cytospin-B

1

3

High-throughput

0.479

High

1219344

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.479

High

1240699

CDC73
Parafibromin

1

1

High-throughput

0.479

High

1257134

PAXI1
PAX-interacting protein 1

1

20

High-throughput

0.479

High

1257948

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

5

High-throughput

0.479

High

1258949

H32
Histone H3.2

1

5

High-throughput

0.479

High

1259510

TBA1A
Tubulin alpha-1A chain

1

6

High-throughput

0.479

High

1280509

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

1281478

ZN467
Zinc finger protein 467

1

4

High-throughput

0.479

High

1287993

PB1
Protein polybromo-1

1

20

High-throughput

0.479

High

1290156

THOC4
THO complex subunit 4

1

6

High-throughput

0.479

High

1307199

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

4

High-throughput

0.479

High

1309372

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

1311284

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

14

High-throughput

0.479

High

1311561

SUGP1
SURP and G-patch domain-containing protein 1

1

2

High-throughput

0.479

High

1323159

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

High-throughput

0.479

High

1338767

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

1340160

KDM2B
Lysine-specific demethylase 2B

1

7

High-throughput

0.479

High

1366439

RT31
Small ribosomal subunit protein mS31

1

1

High-throughput

0.479

High

1369254

JARD2
Protein Jumonji

1

20

High-throughput

0.479

High

1370851

FUBP2
Far upstream element-binding protein 2

1

6

High-throughput

0.479

High

1371698

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.479

High

1385567

ZN524
Zinc finger protein 524

1

5

High-throughput

0.479

High

1389902

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

1390034

PTCD3
Small ribosomal subunit protein mS39

1

1

High-throughput

0.479

High

1394009

SPF45
Splicing factor 45

1

2

High-throughput

0.479

High

1396745

EP400
E1A-binding protein p400

1

20

High-throughput

0.479

High

1399885

TREF1
Transcriptional-regulating factor 1

1

20

High-throughput

0.479

High

1400613

KI20B
Kinesin-like protein KIF20B

1

2

High-throughput

0.479

High

1403023

SIN3A
Paired amphipathic helix protein Sin3a

1

2

High-throughput

0.479

High

1404770

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1405497

SCAFB
Protein SCAF11

1

11

High-throughput

0.479

High

1407785

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

1408537

AKAP9
A-kinase anchor protein 9

1

8

High-throughput

0.479

High

1413344

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.479

High

1416123

RBM4
RNA-binding protein 4

1

9

High-throughput

0.479

High

1416422

SSBP3
Single-stranded DNA-binding protein 3

1

20

High-throughput

0.479

High

1416668

SALL3
Sal-like protein 3

1

17

High-throughput

0.479

High

1416768

CECR2
Chromatin remodeling regulator CECR2

1

20

High-throughput

0.479

High

1420462

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.479

High

1428541

DDX24
ATP-dependent RNA helicase DDX24

1

5

High-throughput

0.479

High

1429048

PRD14
PR domain zinc finger protein 14

1

6

High-throughput

0.479

High

1429161

NAA50
N-alpha-acetyltransferase 50

1

1

High-throughput

0.479

High

1429906

SP130
Histone deacetylase complex subunit SAP130

1

20

High-throughput

0.479

High

1430793

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

6

High-throughput

0.479

High

1430812

ING2
Inhibitor of growth protein 2

1

9

High-throughput

0.479

High

1434922

CCD86
Coiled-coil domain-containing protein 86

1

1

High-throughput

0.479

High

1437217

TF7L1
Transcription factor 7-like 1

1

20

High-throughput

0.479

High

1437218

SHCAF
SIN3-HDAC complex-associated factor

1

4

High-throughput

0.479

High

1437220

SALL1
Sal-like protein 1

1

17

High-throughput

0.479

High

1437224

BCLF1
Bcl-2-associated transcription factor 1

1

5

High-throughput

0.479

High

1437225

IBTK
Inhibitor of Bruton tyrosine kinase

1

5

High-throughput

0.479

High

1437227

TCF20
Transcription factor 20

1

20

High-throughput

0.479

High

1437228

DDX20
Probable ATP-dependent RNA helicase DDX20

1

2

High-throughput

0.479

High

1437233

ING1
Inhibitor of growth protein 1

1

11

High-throughput

0.479

High

1437235

GPTC8
G patch domain-containing protein 8

1

8

High-throughput

0.479

High

1437237

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

6

High-throughput

0.479

High

1437238

YETS2
YEATS domain-containing protein 2

1

20

High-throughput

0.479

High

1437239

AKP8L
A-kinase anchor protein 8-like

1

3

High-throughput

0.479

High

1437240

TRI33
E3 ubiquitin-protein ligase TRIM33

1

11

High-throughput

0.479

High

1437242

SMC3
Structural maintenance of chromosomes protein 3

1

8

High-throughput

0.479

High

1437244

MAN1
Inner nuclear membrane protein Man1

1

2

High-throughput

0.479

High

1437245

NOP58
Nucleolar protein 58

1

1

High-throughput

0.479

High

1437248

RTCB
RNA-splicing ligase RtcB homolog

1

1

High-throughput

0.479

High

1437249

SALL2
Sal-like protein 2

1

15

High-throughput

0.479

High

1437251

SP16H
FACT complex subunit SPT16

1

4

High-throughput

0.479

High

1437252

TF3C3
General transcription factor 3C polypeptide 3

1

7

High-throughput

0.479

High

1437253

MAGD1
Melanoma-associated antigen D1

1

7

High-throughput

0.479

High

1437254

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

1437255

SOX21
Transcription factor SOX-21

1

20

High-throughput

0.479

High

155357

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.458

High

223341

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

262133

NBN
Nibrin

1

0

High-throughput

0.458

High

351358

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.458

High

528354

THIO
Thioredoxin

1

0

High-throughput

0.458

High

709168

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.458

High

848003

RAD52
DNA repair protein RAD52 homolog

1

0

High-throughput

0.458

High

892947

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.458

High

949210

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

1013973

TXN4A
Thioredoxin-like protein 4A

1

0

High-throughput

0.458

High

1032246

EXOSX
Exosome complex component 10

1

0

High-throughput

0.458

High

1128480

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

0

High-throughput

0.458

High

1131399

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.458

High

1147128

ELOC
Elongin-C

1

0

High-throughput

0.458

High

1147853

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.458

High

1153597

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

1208581

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1241165

LTMD1
LETM1 domain-containing protein 1

1

0

High-throughput

0.458

High

1276004

HDX
Highly divergent homeobox

1

0

High-throughput

0.458

High

1287219

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.458

High

1293820

FBX11
F-box only protein 11

1

0

High-throughput

0.458

High

1311320

CDAN1
Codanin-1

1

0

High-throughput

0.458

High

1327464

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.458

High

1331131

PDCD7
Programmed cell death protein 7

1

0

High-throughput

0.458

High

1353789

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.458

High

1371112

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

1391105

TRM61
tRNA

1

0

High-throughput

0.458

High

1403135

CRBN
Protein cereblon

1

0

High-throughput

0.458

High

1436673

VRTN
Vertnin

1

0

High-throughput

0.458

High

1437137

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

0

High-throughput

0.458

High

1437214

ELP3
Elongator complex protein 3

1

0

High-throughput

0.458

High

1437216

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.458

High

1437223

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.458

High

1437229

MUTYH
Adenine DNA glycosylase

1

0

High-throughput

0.458

High

1437230

TRM6
tRNA

1

0

High-throughput

0.458

High

1437232

APC4
Anaphase-promoting complex subunit 4

1

0

High-throughput

0.458

High

1437236

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.458

High

1437256

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.458

High

1214197

LITD1
LINE-1 type transposase domain-containing protein 1

1

1

High-throughput

0.445

High

521441

ARAF
Serine/threonine-protein kinase A-Raf

1

6

Small-scale

0.437

High

597330

PDE6A
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

1

2

High-throughput

0.437

High

641677

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

8

High-throughput

0.437

High

643564

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

3

High-throughput

0.437

High

857181

NSF
Vesicle-fusing ATPase

1

2

High-throughput

0.437

High

894495

PPOX
Protoporphyrinogen oxidase

1

1

High-throughput

0.437

High

992081

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.437

High

1011719

RT35
Small ribosomal subunit protein mS35

1

2

High-throughput

0.437

High

1217841

PR38B
Pre-mRNA-splicing factor 38B

1

4

High-throughput

0.437

High

1233717

TWF2
Twinfilin-2

1

1

High-throughput

0.437

High

1244983

GLD2
Poly(A) RNA polymerase GLD2

1

1

High-throughput

0.437

High

1248200

SAS6
Spindle assembly abnormal protein 6 homolog

1

2

High-throughput

0.437

High

1307851

TPPC5
Trafficking protein particle complex subunit 5

1

1

High-throughput

0.437

High

1325527

FBXW8
F-box/WD repeat-containing protein 8

1

17

Small-scale

0.437

High

1351980

RBCC1
RB1-inducible coiled-coil protein 1

1

4

High-throughput

0.437

High

1360900

MUC16
Mucin-16

1

20

High-throughput

0.437

High

1398165

PCMD1
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1

1

3

High-throughput

0.437

High

1400899

PRAM
PML-RARA-regulated adapter molecule 1

1

20

High-throughput

0.437

High

1437215

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.437

High

1437221

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

1

High-throughput

0.437

High

1437222

PCMD2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

1

3

High-throughput

0.437

High

1437226

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

8

High-throughput

0.437

High

1437243

COF2
Cofilin-2

1

1

High-throughput

0.437

High

1437247

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

1

High-throughput

0.437

High

187800

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.249

Low

283978

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.249

Low

347339

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.249

Low

902223

RAB13
Ras-related protein Rab-13

1

0

High-throughput

0.249

Low

1012767

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.249

Low

1054206

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

High-throughput

0.249

Low

1104112

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.249

Low

1217803

ANGE2
Protein angel homolog 2

1

0

High-throughput

0.249

Low

1278526

TRPM1
Transient receptor potential cation channel subfamily M member 1

1

0

High-throughput

0.249

Low

1292034

AMZ2
Archaemetzincin-2

1

0

High-throughput

0.249

Low

1333548

GT251
Procollagen galactosyltransferase 1

1

0

High-throughput

0.249

Low

1335926

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

1

0

High-throughput

0.249

Low

1383617

RPE
Ribulose-phosphate 3-epimerase

1

0

High-throughput

0.249

Low

1386785

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.249

Low

1401067

PCD15
Protocadherin-15

1

0

High-throughput

0.249

Low

1417445

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.249

Low

1418193

RM09
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.249

Low

1419642

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.249

Low

1433292

TOR3A
Torsin-3A

1

0

High-throughput

0.249

Low

1434698

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

0

High-throughput

0.249

Low

1437219

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025