Protein: APOA1
Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]

Gene: APOA1
Organism: Homo sapiens
Interactions: 168
UniProt ID: P02647

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0001932 - regulation of protein phosphorylation
GO:0001935 - endothelial cell proliferation
GO:0002719 - negative regulation of cytokine production involved in immune response
GO:0005102 - signaling receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

361274

APOA1
Apolipoprotein A-I

12

3

Small-scale

0.982

High

361293

LCAT
Phosphatidylcholine-sterol acyltransferase

8

2

Small-scale

0.748

High

361296

A4
Amyloid-beta precursor protein

5

4

Small-scale

0.721

High

361380

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

4

3

High-throughput

0.709

High

315232

ABCA1
Phospholipid-transporting ATPase ABCA1

4

2

Small-scale

0.692

High

341172

HPT
Haptoglobin

3

1

Small-scale

0.651

High

361349

MK06
Mitogen-activated protein kinase 6

3

0

High-throughput

0.646

High

361298

ALDH2
Aldehyde dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

361325

SYUA
Alpha-synuclein

2

1

Small-scale

0.628

High

361371

AATC2
Putative aspartate aminotransferase, cytoplasmic 2

2

1

High-throughput

0.628

High

361382

SNX27
Sorting nexin-27

2

1

High-throughput

0.628

High

361275

APOA2
Apolipoprotein A-II

3

0

Small-scale

0.613

High

361291

APOB
Apolipoprotein B-100

2

2

Small-scale

0.611

High

361312

LEG3
Galectin-3

2

3

Small-scale

0.611

High

361367

GDPD1
Lysophospholipase D GDPD1

3

1

High-throughput

0.609

High

361384

ZN558
Zinc finger protein 558

3

1

High-throughput

0.609

High

361401

REN3A
Regulator of nonsense transcripts 3A

2

0

High-throughput

0.602

High

361334

CD81
CD81 antigen

2

1

Small-scale

0.601

High

361276

APOC1
Apolipoprotein C-I

2

0

Small-scale

0.588

High

361411

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.585

High

361337

PHLD
Phosphatidylinositol-glycan-specific phospholipase D

1

1

Small-scale

0.561

High

361373

SCRB1
Scavenger receptor class B member 1

1

1

Small-scale

0.561

High

361331

PLTP
Phospholipid transfer protein

1

2

Small-scale

0.550

High

361286

TRFE
Serotransferrin

2

0

High-throughput

0.547

High

155876

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

1

High-throughput

0.541

High

361317

FBLN1
Fibulin-1

1

4

High-throughput

0.541

High

126332

MATN2
Matrilin-2

1

1

High-throughput

0.536

High

198344

KLK10
Kallikrein-10

1

2

High-throughput

0.536

High

361280

C1QA
Complement C1q subcomponent subunit A

1

1

High-throughput

0.536

High

361281

C1QC
Complement C1q subcomponent subunit C

1

1

High-throughput

0.536

High

361285

ALBU
Albumin

1

2

High-throughput

0.536

High

361310

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

361314

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.536

High

361324

K1C9
Keratin, type I cytoskeletal 9

1

1

High-throughput

0.536

High

361336

HBA
Hemoglobin subunit alpha

1

1

High-throughput

0.536

High

361340

PDE4B
3',5'-cyclic-AMP phosphodiesterase 4B

1

1

High-throughput

0.536

High

361345

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.536

High

361351

FNDC1
Fibronectin type III domain-containing protein 1

1

1

High-throughput

0.536

High

361352

FBLN7
Fibulin-7

1

1

High-throughput

0.536

High

361354

TENS3
Tensin-3

1

1

High-throughput

0.536

High

361365

ABCA6
ATP-binding cassette sub-family A member 6

1

2

High-throughput

0.536

High

361378

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.536

High

361389

EGFL8
Epidermal growth factor-like protein 8

1

1

High-throughput

0.536

High

361394

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

361403

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

361410

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

361392

TMM43
Transmembrane protein 43

1

1

High-throughput

0.515

High

361413

SHLB1
Endophilin-B1

1

1

High-throughput

0.515

High

64480

GOG8A
Golgin subfamily A member 8A

1

0

High-throughput

0.513

High

183003

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

217699

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.513

High

276105

CNMD
Leukocyte cell-derived chemotaxin 1

1

0

High-throughput

0.513

High

328085

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.513

High

336752

CERU
Ceruloplasmin

1

0

High-throughput

0.513

High

361278

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.513

High

361279

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

0

High-throughput

0.513

High

361282

FINC
Fibronectin

1

0

High-throughput

0.513

High

361284

TTHY
Transthyretin

1

0

High-throughput

0.513

High

361290

TDT
DNA nucleotidylexotransferase

1

0

High-throughput

0.513

High

361294

K2C1
Keratin, type II cytoskeletal 1

1

0

High-throughput

0.513

High

361299

CATL1
Procathepsin L

1

0

High-throughput

0.513

High

361302

K1C16
Keratin, type I cytoskeletal 16

1

0

High-throughput

0.513

High

361303

DHPR
Dihydropteridine reductase

1

0

High-throughput

0.513

High

361307

CLUS
Clusterin

1

0

High-throughput

0.513

High

361323

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

361326

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.513

High

361330

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

0

High-throughput

0.513

High

361333

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

361338

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

361339

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.513

High

361344

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.513

High

361368

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.513

High

361370

O13C3
Olfactory receptor 13C3

1

0

High-throughput

0.513

High

361372

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

0

High-throughput

0.513

High

361374

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

361375

ASM3A
Cyclic GMP-AMP phosphodiesterase SMPDL3A

1

0

High-throughput

0.513

High

361381

MOCOS
Molybdenum cofactor sulfurase

1

0

High-throughput

0.513

High

361383

ROBO3
Roundabout homolog 3

1

0

High-throughput

0.513

High

361395

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

0

High-throughput

0.513

High

361398

SPEF2
Sperm flagellar protein 2

1

0

High-throughput

0.513

High

361404

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.513

High

361396

TRI15
E3 ubiquitin-protein ligase TRIM15

1

1

Small-scale

0.512

High

361360

BRAP
BRCA1-associated protein

1

1

Small-scale

0.508

High

361376

NDRG1
Protein NDRG1

1

0

Small-scale

0.504

High

361295

VWF
von Willebrand factor

1

1

Small-scale

0.501

High

361300

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.501

High

361361

ABCAD
ATP-binding cassette sub-family A member 13

1

2

Small-scale

0.501

High

361406

TREM2
Triggering receptor expressed on myeloid cells 2

1

1

Small-scale

0.501

High

361350

MA7D1
MAP7 domain-containing protein 1

1

1

High-throughput

0.494

High

361400

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.493

High

361308

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

361353

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

1

High-throughput

0.489

High

361362

TXND2
Thioredoxin domain-containing protein 2

1

1

High-throughput

0.489

High

361385

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

1

High-throughput

0.489

High

361408

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

361357

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.486

High

361322

AKT2
RAC-beta serine/threonine-protein kinase

1

1

High-throughput

0.481

High

361329

PDE1A
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

1

1

Small-scale

0.481

High

361301

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

0

High-throughput

0.479

High

121069

LEG8
Galectin-8

1

3

Small-scale

0.479

High

301517

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

361277

APOC2
Apolipoprotein C-II

1

1

High-throughput

0.479

High

361287

HEMO
Hemopexin

1

2

High-throughput

0.479

High

361292

GCR
Glucocorticoid receptor

1

1

Small-scale

0.479

High

361313

LBP
Lipopolysaccharide-binding protein

1

2

Small-scale

0.479

High

361318

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.479

High

361327

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

361335

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.479

High

361341

FOXO1
Forkhead box protein O1

1

2

High-throughput

0.479

High

361377

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

361393

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

361397

TRIM6
Tripartite motif-containing protein 6

1

1

Small-scale

0.479

High

361304

SAA2
Serum amyloid A-2 protein

1

0

Small-scale

0.460

High

361306

OSTP
Osteopontin

1

0

High-throughput

0.460

High

361328

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.460

High

344138

A1AT
Alpha-1-antitrypsin

1

0

High-throughput

0.458

High

361283

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

361288

STAT
Statherin

1

0

High-throughput

0.458

High

361289

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

361309

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

361311

CXA1
Gap junction alpha-1 protein

1

0

Small-scale

0.458

High

361315

ATP4A
Potassium-transporting ATPase alpha chain 1

1

0

Small-scale

0.458

High

361320

CD40L
CD40 ligand

1

0

Small-scale

0.458

High

361321

LCN1
Lipocalin-1

1

0

High-throughput

0.458

High

361332

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

361346

CUL7
Cullin-7

1

0

High-throughput

0.458

High

361348

PROL4
Proline-rich protein 4

1

0

High-throughput

0.458

High

361369

NNRE
NAD(P)H-hydrate epimerase

1

0

Small-scale

0.458

High

361386

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

361414

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

Small-scale

0.458

High

361415

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.458

High

361316

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

High-throughput

0.457

High

353483

IGKC
Immunoglobulin kappa constant

1

3

High-throughput

0.445

High

353601

IGHG1
Immunoglobulin heavy constant gamma 1

1

3

High-throughput

0.445

High

353902

IGHM
Immunoglobulin heavy constant mu

1

3

High-throughput

0.445

High

354017

IGHA1
Immunoglobulin heavy constant alpha 1

1

3

High-throughput

0.445

High

260436

PITX3
Pituitary homeobox 3

1

1

Small-scale

0.437

High

361358

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.437

High

361364

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

361387

EYA1
Eyes absent homolog 1

1

1

High-throughput

0.437

High

361399

ASXL3
Putative Polycomb group protein ASXL3

1

3

High-throughput

0.437

High

155707

APOL1
Apolipoprotein L1

1

0

Small-scale

0.426

High

277426

DGAT1
Diacylglycerol O-acyltransferase 1

1

0

Small-scale

0.426

High

353182

KVD40
Immunoglobulin kappa variable 2D-40

1

0

High-throughput

0.426

High

361297

APOD
Apolipoprotein D

1

0

Small-scale

0.426

High

361342

APOF
Apolipoprotein F

1

0

Small-scale

0.426

High

361402

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.328

High

361347

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.282

High

361407

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.282

High

297807

K0754
Microtubule-actin cross-linking factor 1, isoforms 6/7

1

0

High-throughput

0.279

Low

331684

NSD2
Histone-lysine N-methyltransferase NSD2

1

0

High-throughput

0.279

Low

361356

SFXN4
Sideroflexin-4

1

0

High-throughput

0.279

Low

361359

SETX
Probable helicase senataxin

1

0

High-throughput

0.279

Low

361363

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.279

Low

361366

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

0

High-throughput

0.279

Low

361379

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

361388

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

361391

FA83C
Protein FAM83C

1

0

High-throughput

0.279

Low

361405

KLH28
Kelch-like protein 28

1

0

High-throughput

0.279

Low

361409

SRTD3
SERTA domain-containing protein 3

1

0

High-throughput

0.279

Low

361412

CD11A
Cyclin-dependent kinase 11A

1

0

High-throughput

0.279

Low

361416

F169A
Soluble lamin-associated protein of 75 kDa

1

0

High-throughput

0.279

Low

361390

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

361319

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

361343

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.249

Low

361355

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.249

Low

361305

POK10
Endogenous retrovirus group K member 10 Pol protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024