HitPredict

Interactor 1: GLIS3 (Q8NEA6)
Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515)
Gene: GLIS3

Interactor 2: SUFU (Q9UMX1)
Suppressor of fused homolog (SUFUH)
Gene: SUFU

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	26147758, 16189514, 21543335, 20211142
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 775 Hs			1 484
+	Mm
		1142949 GLI3_MOUSE (104-647): 2.43e-110: 370: 31.30		SUFU_MOUSE (1-484): 0: 914: 97.73
+	Hs
		485150 GLI3_HUMAN (105-647): 6.59e-111: 371: 31.66		SUFU_HUMAN (1-484): 0: 912: 100.00
+	Mm
		1012691 GLI2_MOUSE (94-618): 1.26e-109: 367: 35.62		SUFU_MOUSE (1-484): 0: 914: 97.73
+	Hs
		485095 GLI2_HUMAN (94-619): 4.58e-109: 366: 36.20		SUFU_HUMAN (1-484): 0: 912: 100.00
+	Mm
		814025 GLI1_MOUSE (137-574): 1.98e-88: 303: 36.65		SUFU_MOUSE (1-484): 0: 914: 97.73
+	Hs
		436760 GLI1_HUMAN (115-602): 5.76e-86: 296: 35.37		SUFU_HUMAN (1-484): 0: 912: 100.00
+	Dr
		1193346 Q9YGS4_DANRE (94-588): 9.37e-98: 333: 33.08		Q7ZVZ9_DANRE (16-484): 0: 846: 80.95
+	Hs
		1080643 ZIC1_HUMAN (347-496): 3.5e-40: 155: 49.38		SUFU_HUMAN (1-484): 0: 912: 100.00
+	Dr
		1193345 Q800Z9_DANRE (347-549): 1.92e-51: 196: 55.71		Q7ZVZ9_DANRE (16-484): 0: 846: 80.95
+	Dm
		585801 CI_DROME (347-506): 4.2e-53: 201: 63.98		Q9VG38_DROME (31-484): 0: 662: 37.71
+	Dm
		585716 CI_DROME (347-506): 4.2e-53: 201: 63.98		Q27279_DROME (31-484): 0: 656: 37.50