HitPredict

Interactor 1: KDM2B (Q8NHM5)
Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)
Gene: KDM2B

Interactor 2: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.760

Property	Details
Experiments	26687479, 27705803, 27505670, 29985131, 32628469, 33961781, 16943429, 22325352, 25533466, 29502955, 24981860, 23395003
Identification Methods	affinity chromatography technology, biochemical, tandem affinity purification, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0031519 - PcG protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1336 Hs			1 259
+	Hs
		718034 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		718413 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		1108521 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Mm
		1158236 KDM2B_MOUSE (43-1336): 0: 1146: 94.45		PCGF1_MOUSE (1-259): 1.69e-82: 249: 98.07
+	Hs
		1245594 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		1197574 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		PCGF5_HUMAN (30-257): 3.38e-44: 151: 29.41
+	Hs
		1245587 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Mm
		639474 KDM2B_MOUSE (43-1336): 0: 1146: 94.45		BMI1_MOUSE (30-255): 1.56e-62: 200: 35.59
+	Hs
		987996 KDM2B_HUMAN (1-1336): 0: 1220: 100.00		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Mm
		1158239 KDM2B_MOUSE (43-1336): 0: 1146: 94.45		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Mm
		193408 KDM2B_MOUSE (43-1336): 0: 1146: 94.45		RING1_MOUSE (24-155): 5.39e-33: 125: 20.59
+	Hs
		718320 PHF8_HUMAN (22-1018): 0: 637: 20.63		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Dm
		627171 JHD1_DROME (46-1233): 0: 600: 24.77		SUZ2_DROME (13-254): 7.25e-51: 180: 26.61
+	Dm
		728809 JHD1_DROME (46-1233): 0: 600: 24.77		PSC_DROME (26-256): 4.12e-50: 178: 28.63
+	Dm
		1367224 JHD1_DROME (46-1233): 0: 600: 24.77		Q9VV77_DROME (32-257): 1.29e-53: 174: 39.30
+	Hs
		1019385 PHF8_HUMAN (22-1018): 0: 637: 20.63		TRI26_HUMAN (32-223): 6.79e-32: 124: 19.90
+	Dm
		1361711 JHD1_DROME (46-1233): 0: 600: 24.77		RING1_DROME (24-153): 5.81e-31: 120: 24.63
+	Hs
		1311563 KDM2A_HUMAN (845-1336): 9.67e-66: 246: 41.46		PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00
+	Hs
		718044 FBX41_HUMAN (771-1298): 6.44e-50: 194: 18.11		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		584946 SKP2_HUMAN (981-1333): 1.57e-47: 178: 17.91		RO52_HUMAN (32-226): 9.58e-36: 134: 18.61