HitPredict

Interactor 1: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Interactor 2: TEP1 (Q99973)
Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog)
Gene: TEP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 731 Hs			1 2627
+	Hs
		903378 COP1_HUMAN (1-731): 0: 540: 100.00		WDR5_HUMAN (2349-2627): 1.13e-62: 220: 12.72
+	Hs
		921653 COP1_HUMAN (1-731): 0: 540: 100.00		GBB2_HUMAN (2093-2365): 2.79e-41: 158: 20.14
+	Hs
		254111 FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15		WDR1_HUMAN (1545-2039): 3.11e-69: 248: 15.55
+	Hs
		903418 FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15		WDR5_HUMAN (2349-2627): 1.13e-62: 220: 12.72
+	Hs
		903349 WDR5B_HUMAN (336-625): 1.65e-63: 216: 17.79		WDR5_HUMAN (2349-2627): 1.13e-62: 220: 12.72
+	Hs
		792949 LIS1_HUMAN (509-730): 2.11e-55: 197: 21.24		WDR5_HUMAN (2349-2627): 1.13e-62: 220: 12.72
+	Hs
		196984 PRP4_HUMAN (511-730): 7.51e-41: 159: 16.59		WDR5_HUMAN (2349-2627): 1.13e-62: 220: 12.72
+	Sc
		744660 TAF5_YEAST (96-683): 1.17e-82: 280: 14.26		COPA_YEAST (2243-2391): 1.1e-16: 89.4: 14.38
+	Hs
		1240442 POC1A_HUMAN (455-731): 4.3e-69: 234: 22.94		POC1B_HUMAN (1531-1744): 2.71e-30: 129: 8.47
+	Hs
		903551 NLE1_HUMAN (582-729): 3.62e-35: 141: 15.33		WDR5_HUMAN (2349-2627): 1.13e-62: 220: 12.72
+	Hs
		1281292 FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15		FBXW7_HUMAN (2393-2625): 1.34e-22: 107: 12.08
+	Sc
		784397 COPB2_YEAST (411-723): 4.62e-66: 236: 20.13		COPA_YEAST (2243-2391): 1.1e-16: 89.4: 14.38
+	Hs
		792935 LIS1_HUMAN (509-730): 2.11e-55: 197: 21.24		LIS1_HUMAN (2276-2586): 5.31e-30: 127: 11.04
+	Mm
		925836 LIS1_MOUSE (509-730): 1.47e-55: 197: 21.24		LIS1_MOUSE (2276-2586): 5.31e-30: 127: 11.04
+	Hs
		903171 RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49		WDR5_HUMAN (2349-2627): 1.13e-62: 220: 12.72
+	Hs
		921751 NLE1_HUMAN (582-729): 3.62e-35: 141: 15.33		GBB2_HUMAN (2093-2365): 2.79e-41: 158: 20.14
+	Hs
		197071 PRP4_HUMAN (511-730): 7.51e-41: 159: 16.59		SNR40_HUMAN (2057-2325): 4.81e-22: 102: 26.34
+	Hs
		1346954 NLE1_HUMAN (582-729): 3.62e-35: 141: 15.33		NLE1_HUMAN (2501-2625): 3.64e-25: 114: 12.21
+	Sc
		630844 NLE1_YEAST (595-731): 6.37e-32: 132: 19.01		NLE1_YEAST (2347-2625): 3.64e-28: 123: 9.88