HitPredict

Interactor 1: CHM4 (Q8T0Q4)
Charged multivesicular body protein 4 (CHMP4) (ESCRT-III complex core component shrb) (Protein Shrub)
Gene: shrb

Interactor 2: CHMP5 (Q9VVI9)
Charged multivesicular body protein 5 (Vacuolar protein-sorting-associated protein 60)
Gene: Vps60

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000815 - ESCRT III complex GO:0005771 - multivesicular body GO:0006900 - vesicle budding from membrane GO:0032509 - endosome transport via multivesicular body sorting pathway GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway and 1 others more... GO:0046718 - symbiont entry into host cell
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 226 Dm			1 226
+	Hs
		92838 E9PSI1_HUMAN (1-202): 3.11e-57: 195: 55.07		CHM4B_HUMAN (15-214): 1.97e-26: 103: 23.27
+	Ce
		183904 Q18886_CAEEL (1-226): 7.27e-48: 158: 55.51		O16458_CAEEL (1-221): 1.63e-34: 124: 54.05
+	Dm
		1249811 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		CHM4_DROME (7-222): 3.8e-31: 115: 24.42
+	Ce
		1090380 Q18886_CAEEL (1-226): 7.27e-48: 158: 55.51		Q9U2F6_CAEEL (5-208): 1.26e-31: 117: 18.63
+	Dm
		1249819 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q9VN02_DROME (4-219): 1.39e-28: 109: 12.96
+	Zm
		77175 B4FU00_MAIZE (4-213): 9.73e-40: 137: 20.74		B4FU00_MAIZE (1-222): 4.76e-38: 133: 36.28
+	Hs
		1260649 CHM4C_HUMAN (1-226): 4.9e-42: 144: 48.50		CHMP7_HUMAN (5-222): 2.27e-32: 123: 19.91
+	Dm
		1249820 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q9VRJ5_DROME (2-211): 2.4e-25: 100: 12.86
+	Dm
		1249815 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q9VBI3_DROME (7-208): 8.28e-25: 99.8: 17.82
+	Dm
		1249823 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q9W236_DROME (1-209): 3.12e-22: 92.2: 20.28
+	Hs
		1286650 CHM4C_HUMAN (1-226): 4.9e-42: 144: 48.50		CHM4C_HUMAN (6-218): 5.18e-29: 110: 17.51
+	Hs
		1286687 CHM4C_HUMAN (1-226): 4.9e-42: 144: 48.50		CHM4A_HUMAN (1-219): 7.26e-27: 104: 22.27
+	Hs
		1286698 CHM4C_HUMAN (1-226): 4.9e-42: 144: 48.50		CHM4B_HUMAN (15-214): 1.97e-26: 103: 23.27
+	At
		287073 VP601_ARATH (4-217): 2.12e-41: 142: 19.91		VP321_ARATH (1-223): 5.43e-27: 104: 27.35
+	At
		98408 F4JXR3_ARATH (4-217): 1.56e-41: 144: 17.05		VP322_ARATH (1-223): 2.66e-26: 102: 26.67
+	At
		1013158 VP601_ARATH (4-217): 2.12e-41: 142: 19.91		VPS2B_ARATH (7-190): 1.33e-26: 103: 16.85
+	At
		1339085 VP601_ARATH (4-217): 2.12e-41: 142: 19.91		VP322_ARATH (1-223): 2.66e-26: 102: 26.67
+	Hs
		1260658 CHMP7_HUMAN (3-221): 1.35e-37: 137: 23.71		CHM4A_HUMAN (1-219): 7.26e-27: 104: 22.27
+	Hs
		1260663 CHMP7_HUMAN (3-221): 1.35e-37: 137: 23.71		CHM4B_HUMAN (15-214): 1.97e-26: 103: 23.27