HitPredict

Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization GO:0043025 - neuronal cell body GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2390 Hs			1 191
+	Hs
		164564 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		564483 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		164665 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		164599 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		963416 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		925201 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		164602 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		164593 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		893910 SPTB2_HUMAN (3-2390): 0: 712: 61.09		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		950929 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		900386 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545327 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		164556 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		164589 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		436258 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		892322 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		164633 SPTN2_HUMAN (1-2390): 0: 715: 100.00		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		963356 SPTB2_HUMAN (3-2390): 0: 712: 61.09		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		545254 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436196 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41