HitPredict

Interactor 1: PSMA8 (Q8TAA3)
Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)
Gene: PSMA8

Interactor 2: PSB7 (Q99436)
Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z)
Gene: PSMB7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.897

Property	Details
Experiments	26186194, 28514442, 33961781, 17948026
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pr_beta_C~Proteasome, Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 256 Hs			1 277
+	Hs
		156341 PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91		PSB7_HUMAN (1-277): 2.34e-107: 314: 100.00
+	Hs
		656276 PSMA8_HUMAN (1-238): 1.86e-105: 307: 100.00		PSA5_HUMAN (13-240): 3.35e-81: 246: 18.67
+	At
		286453 PSA6B_ARATH (2-243): 7.33e-94: 277: 32.11		PSB7B_ARATH (1-275): 2.81e-91: 273: 57.04
+	Sc
		625941 PSA4_YEAST (3-240): 2.45e-102: 299: 54.77		PSB2_YEAST (11-272): 6.97e-82: 248: 54.92
+	At
		188701 PSA6B_ARATH (2-243): 7.33e-94: 277: 32.11		PSB7A_ARATH (1-275): 1.06e-89: 269: 56.16
+	Hs
		156230 PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91		PSA5_HUMAN (13-240): 3.35e-81: 246: 18.67
+	Dm
		611671 PSA71_DROME (1-237): 2.13e-94: 279: 69.20		Q9VUJ1_DROME (10-277): 2.75e-87: 262: 64.82
+	Hs
		656629 PSMA8_HUMAN (1-238): 1.86e-105: 307: 100.00		PSB6_HUMAN (41-229): 3.57e-76: 233: 31.58
+	Hs
		156228 PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91		PSB8_HUMAN (31-243): 3.86e-78: 239: 24.30
+	Sc
		689186 PSA4_YEAST (3-240): 2.45e-102: 299: 54.77		PSA5_YEAST (13-253): 6.07e-77: 236: 20.62
+	Hs
		156232 PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91		PSB6_HUMAN (41-229): 3.57e-76: 233: 31.58
+	Hs
		156233 PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91		PSB5_HUMAN (42-243): 1.28e-74: 230: 26.11
+	Sc
		675422 PSA4_YEAST (3-240): 2.45e-102: 299: 54.77		PSB5_YEAST (5-246): 1.85e-70: 220: 22.54
+	Dm
		611640 PSA71_DROME (1-237): 2.13e-94: 279: 69.20		Q7K148_DROME (5-251): 4.24e-78: 239: 26.91
+	Dm
		611647 PSA71_DROME (1-237): 2.13e-94: 279: 69.20		PSA5_DROME (13-242): 1.22e-78: 239: 17.14
+	Sc
		751166 PSA4_YEAST (3-240): 2.45e-102: 299: 54.77		PSB1_YEAST (43-222): 1.62e-26: 104: 32.04
+	Hs
		656127 PSMA8_HUMAN (1-238): 1.86e-105: 307: 100.00		PSB9_HUMAN (42-227): 9.71e-21: 89.7: 29.41
+	Hs
		156229 PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91		PSB9_HUMAN (42-227): 9.71e-21: 89.7: 29.41
+	Af
		191426 PSA_ARCFU (4-250): 4.26e-96: 283: 43.15		PSB_ARCFU (43-234): 1.16e-24: 99.8: 33.33
+	Dm
		47596 PSA71_DROME (1-237): 2.13e-94: 279: 69.20		A0AQH0_DROME (42-227): 1.55e-22: 94.4: 29.41