HitPredict

Interactor 1: VANG1 (Q8TAA9)
Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)
Gene: VANGL1

Interactor 2: DVL3 (Q92997)
Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)
Gene: DVL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 524 Hs			1 716
+	Mm
		1142090 VANG1_MOUSE (1-524): 0: 805: 95.06		DVL3_MOUSE (1-716): 4.23e-172: 512: 99.02
+	Mm
		844428 VANG1_MOUSE (1-524): 0: 805: 95.06		DVL1_MOUSE (1-716): 3.66e-157: 473: 62.83
+	Hs
		151096 VANG1_HUMAN (1-524): 0: 822: 100.00		DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13
+	Mm
		1141500 VANG1_MOUSE (1-524): 0: 805: 95.06		DVL2_MOUSE (3-716): 2.64e-136: 420: 64.80
+	Mm
		1142094 VANG2_MOUSE (1-524): 0: 671: 71.86		DVL3_MOUSE (1-716): 4.23e-172: 512: 99.02
+	Mm
		844432 VANG2_MOUSE (1-524): 0: 671: 71.86		DVL1_MOUSE (1-716): 3.66e-157: 473: 62.83
+	Mm
		1141507 VANG2_MOUSE (1-524): 0: 671: 71.86		DVL2_MOUSE (3-716): 2.64e-136: 420: 64.80
+	Hs
		151251 VANG2_HUMAN (1-524): 0: 668: 72.05		DVL2_HUMAN (3-716): 2.33e-133: 412: 65.13
+	Dm
		219854 O45030_DROME (21-524): 0: 689: 45.02		DSH_DROME (3-558): 5.64e-101: 324: 46.13
+	Dm
		52640 A1Z7N9_DROME (21-524): 0: 689: 45.02		DSH_DROME (3-558): 5.64e-101: 324: 46.13
+	Hs
		1021536 VANG1_HUMAN (1-524): 0: 822: 100.00		DLG1_HUMAN (113-656): 1.76e-42: 167: 14.34
+	Mm
		1143382 VANG1_MOUSE (1-524): 0: 805: 95.06		DLG4_MOUSE (91-649): 6.72e-43: 167: 13.22
+	Ce
		109389 H2KY90_CAEEL (2-524): 0: 674: 32.97		Q18239_CAEEL (4-626): 4.09e-89: 297: 31.14
+	Hs
		1250786 VANG1_HUMAN (1-524): 0: 822: 100.00		PARD3_HUMAN (200-415): 1.34e-19: 96.2: 20.00
+	Hs
		883931 VANG1_HUMAN (1-524): 0: 822: 100.00		SYJ2B_HUMAN (247-322): 4.13e-14: 71.8: 33.75
+	Mm
		1143470 VANG2_MOUSE (1-524): 0: 671: 71.86		DLG4_MOUSE (91-649): 6.72e-43: 167: 13.22
+	Rn
		677774 VANG2_RAT (1-524): 0: 671: 71.86		DLG4_RAT (91-649): 1.39e-42: 166: 13.19
+	Mm
		1193536 VANG2_MOUSE (1-524): 0: 671: 71.86		SCRIB_MOUSE (57-647): 2.05e-26: 118: 14.50
+	Ce
		101922 H2KY90_CAEEL (2-524): 0: 674: 32.97		G1K0W3_CAEEL (249-329): 6.61e-11: 68: 26.09
+	Hs
		883951 VANG2_HUMAN (1-524): 0: 668: 72.05		SYJ2B_HUMAN (247-322): 4.13e-14: 71.8: 33.75