Protein: MPRIP
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)

Gene: MPRIP
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q6WCQ1

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005925 - focal adhesion
GO:0015629 - actin cytoskeleton
GO:0045296 - cadherin binding
GO:0051015 - actin filament binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1250788

ANLN
Anillin

4

11

High-throughput

0.895

High

920052

PLK1
Serine/threonine-protein kinase PLK1

3

6

High-throughput

0.871

High

962185

RHOA
Transforming protein RhoA

3

20

Small-scale

0.858

High

1250806

FBW1A
F-box/WD repeat-containing protein 1A

2

15

High-throughput

0.811

High

710317

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.754

High

691149

1433T
14-3-3 protein theta

9

20

High-throughput

0.751

High

729971

1433B
14-3-3 protein beta/alpha

7

20

High-throughput

0.744

High

177387

ARHGB
Rho guanine nucleotide exchange factor 11

2

18

High-throughput

0.737

High

966495

1433G
14-3-3 protein gamma

6

20

High-throughput

0.732

High

990378

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.712

High

1250767

WDR83
WD repeat domain-containing protein 83

2

13

High-throughput

0.705

High

1250804

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

4

11

High-throughput

0.699

High

667913

CDK2
Cyclin-dependent kinase 2

1

13

High-throughput

0.691

High

1250779

TARA
TRIO and F-actin-binding protein

1

19

High-throughput

0.691

High

1049450

1433F
14-3-3 protein eta

4

20

High-throughput

0.691

High

610381

PRS6A
26S proteasome regulatory subunit 6A

3

8

High-throughput

0.667

High

1250722

MPRIP
Myosin phosphatase Rho-interacting protein

1

18

Small-scale

0.665

High

1250770

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

3

12

High-throughput

0.662

High

1250794

VAPA
Vesicle-associated membrane protein-associated protein A

3

6

High-throughput

0.662

High

1228421

FTM
Protein fantom

3

20

High-throughput

0.657

High

396367

ESR1
Estrogen receptor

3

20

Small-scale

0.633

High

333060

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

6

High-throughput

0.628

High

1250778

RGAP1
Rac GTPase-activating protein 1

1

10

High-throughput

0.621

High

951723

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

5

Small-scale

0.619

High

244261

NUAK1
NUAK family SNF1-like kinase 1

1

10

High-throughput

0.618

High

355001

CHK2
Serine/threonine-protein kinase Chk2

1

13

High-throughput

0.618

High

126661

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

136102

PLK4
Serine/threonine-protein kinase PLK4

1

18

Small-scale

0.618

High

157526

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.618

High

363450

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

401024

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.618

High

440126

LCK
Tyrosine-protein kinase Lck

1

15

High-throughput

0.618

High

876903

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.618

High

962773

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

978101

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1115747

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.618

High

1140452

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.618

High

1153006

MYLK
Myosin light chain kinase, smooth muscle

1

11

High-throughput

0.618

High

1159508

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

1209297

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

Small-scale

0.618

High

1226915

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.618

High

1250723

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

20

High-throughput

0.618

High

1250726

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1250750

FBXW7
F-box/WD repeat-containing protein 7

1

17

High-throughput

0.618

High

1250763

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

3

Small-scale

0.618

High

1250765

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

9

High-throughput

0.618

High

1250766

MEP50
Methylosome protein WDR77

1

18

High-throughput

0.618

High

1250769

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.618

High

1250784

ECT2
Protein ECT2

1

20

High-throughput

0.618

High

1250785

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1250807

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

4

High-throughput

0.618

High

971669

1433E
14-3-3 protein epsilon

2

7

High-throughput

0.611

High

1250729

NAA40
N-alpha-acetyltransferase 40

2

3

High-throughput

0.611

High

1250736

ZFP41
Zinc finger protein 41 homolog

3

1

High-throughput

0.609

High

563952

CFTR
Cystic fibrosis transmembrane conductance regulator

2

11

High-throughput

0.601

High

730695

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

1250808

SERC
Phosphoserine aminotransferase

2

1

High-throughput

0.601

High

582845

EZRI
Ezrin

2

20

High-throughput

0.584

High

830949

CCNF
Cyclin-F

2

7

High-throughput

0.584

High

862240

YAP1
Transcriptional coactivator YAP1

2

20

High-throughput

0.584

High

952911

ACTB
Actin, cytoplasmic 1

2

20

High-throughput

0.584

High

942691

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.575

High

987719

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.575

High

1234831

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.575

High

1250798

FBW1B
F-box/WD repeat-containing protein 11

1

14

High-throughput

0.575

High

1250756

JPH4
Junctophilin-4

2

3

High-throughput

0.574

High

171264

MYPT1
Protein phosphatase 1 regulatory subunit 12A

2

17

Small-scale

0.571

High

1143371

PCM1
Pericentriolar material 1 protein

2

3

High-throughput

0.571

High

1217688

SYDE2
Rho GTPase-activating protein SYDE2

2

13

High-throughput

0.571

High

1250772

PP12C
Protein phosphatase 1 regulatory subunit 12C

2

20

Small-scale

0.566

High

1250782

FNDC4
Fibronectin type III domain-containing protein 4

2

11

High-throughput

0.558

High

641200

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.553

High

711908

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.553

High

123743

MYO1C
Unconventional myosin-Ic

1

18

High-throughput

0.536

High

158658

TYB4Y
Thymosin beta-4, Y-chromosomal

1

1

High-throughput

0.536

High

277935

SH3L1
Adapter SH3BGRL

1

1

High-throughput

0.536

High

457105

CAN1
Calpain-1 catalytic subunit

1

4

High-throughput

0.536

High

568333

ACPH
Acylamino-acid-releasing enzyme

1

5

High-throughput

0.536

High

637585

FLNA
Filamin-A

1

14

High-throughput

0.536

High

772866

MYH9
Myosin-9

1

19

High-throughput

0.536

High

862883

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

13

High-throughput

0.536

High

866733

CAZA2
F-actin-capping protein subunit alpha-2

1

11

High-throughput

0.536

High

867222

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.536

High

882517

ARRB1
Beta-arrestin-1

1

4

High-throughput

0.536

High

968352

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

20

High-throughput

0.536

High

983853

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

High-throughput

0.536

High

1030662

ANK2
Ankyrin-2

1

14

High-throughput

0.536

High

1052047

CALD1
Caldesmon

1

20

High-throughput

0.536

High

1124629

SRC8
Src substrate cortactin

1

19

High-throughput

0.536

High

1160665

DREB
Drebrin

1

7

High-throughput

0.536

High

1161502

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.536

High

1248421

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

6

High-throughput

0.536

High

1250732

H2B3B
Histone H2B type 3-B

1

13

High-throughput

0.536

High

1250734

SYNPO
Synaptopodin

1

9

High-throughput

0.536

High

1250747

MY18A
Unconventional myosin-XVIIIa

1

19

High-throughput

0.536

High

1250755

MYO19
Unconventional myosin-XIX

1

19

High-throughput

0.536

High

1250789

PDLI7
PDZ and LIM domain protein 7

1

11

High-throughput

0.536

High

1250796

LIMA1
LIM domain and actin-binding protein 1

1

12

High-throughput

0.536

High

1250799

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

12

High-throughput

0.536

High

1250802

TPX2
Targeting protein for Xklp2

1

2

High-throughput

0.536

High

372360

MYC
Myc proto-oncogene protein

2

15

High-throughput

0.533

High

695760

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

9

High-throughput

0.533

High

1118067

DX39B
Spliceosome RNA helicase DDX39B

2

11

Small-scale

0.533

High

1224799

AP1AR
AP-1 complex-associated regulatory protein

1

1

High-throughput

0.515

High

1250786

CPAP
Centrosomal P4.1-associated protein

1

19

High-throughput

0.515

High

1250776

NUAK2
NUAK family SNF1-like kinase 2

1

10

High-throughput

0.514

High

1250737

NECA1
N-terminal EF-hand calcium-binding protein 1

1

0

High-throughput

0.513

High

1250761

TRNT1
CCA tRNA nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

1250793

MTMRA
Myotubularin-related protein 10

1

0

High-throughput

0.513

High

184721

ATX7
Ataxin-7

1

6

High-throughput

0.508

High

713106

NOS3
Nitric oxide synthase 3

1

1

High-throughput

0.508

High

1250749

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

14

High-throughput

0.501

High

249153

DSCAM
Cell adhesion molecule DSCAM

1

4

High-throughput

0.494

High

903188

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

8

High-throughput

0.494

High

277369

TP4A3
Protein tyrosine phosphatase type IVA 3

1

9

High-throughput

0.489

High

317072

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

3

High-throughput

0.489

High

354021

CX001
Putative transmembrane protein CXorf1

1

2

High-throughput

0.489

High

399585

VTNC
Vitronectin

1

1

High-throughput

0.489

High

600323

ZNF24
Zinc finger protein 24

1

3

High-throughput

0.489

High

1009618

CXCL6
C-X-C motif chemokine 6

1

2

High-throughput

0.489

High

1092771

MALL
MAL-like protein

1

2

High-throughput

0.489

High

1093754

GAGE5
G antigen 5

1

3

High-throughput

0.489

High

1154269

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

3

High-throughput

0.489

High

1250742

HASP
Serine/threonine-protein kinase haspin

1

1

High-throughput

0.489

High

1250745

JPH3
Junctophilin-3

1

3

High-throughput

0.489

High

1250752

OTUB2
Ubiquitin thioesterase OTUB2

1

1

High-throughput

0.489

High

1250753

ERLEC
Endoplasmic reticulum lectin 1

1

2

High-throughput

0.489

High

1250801

ANR50
Ankyrin repeat domain-containing protein 50

1

13

High-throughput

0.489

High

1250809

NEMO
NF-kappa-B essential modulator

1

19

High-throughput

0.481

High

164367

NRP1
Neuropilin-1

1

12

High-throughput

0.479

High

345969

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

11

High-throughput

0.479

High

370704

FOS
Protein c-Fos

1

5

High-throughput

0.479

High

425546

ISG15
Ubiquitin-like protein ISG15

1

14

High-throughput

0.479

High

459640

PROF1
Profilin-1

1

4

High-throughput

0.479

High

535214

BIP
Endoplasmic reticulum chaperone BiP

1

12

High-throughput

0.479

High

556167

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

629923

BTF3
Transcription factor BTF3

1

7

High-throughput

0.479

High

680919

PSA1
Proteasome subunit alpha type-1

1

2

High-throughput

0.479

High

693009

DPP4
Dipeptidyl peptidase 4

1

5

High-throughput

0.479

High

702003

TMOD1
Tropomodulin-1

1

5

High-throughput

0.479

High

764845

CTNB1
Catenin beta-1

1

13

High-throughput

0.479

High

767457

RADI
Radixin

1

19

High-throughput

0.479

High

774441

BASI
Basigin

1

8

High-throughput

0.479

High

786682

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

20

High-throughput

0.479

High

907475

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

18

High-throughput

0.479

High

929977

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

7

High-throughput

0.479

High

958131

ARP3
Actin-related protein 3

1

20

High-throughput

0.479

High

995653

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.479

High

1035713

KIF23
Kinesin-like protein KIF23

1

18

High-throughput

0.479

High

1086246

TFCP2
Alpha-globin transcription factor CP2

1

5

High-throughput

0.479

High

1107847

SQSTM
Sequestosome-1

1

7

High-throughput

0.479

High

1137794

TNIP1
TNFAIP3-interacting protein 1

1

19

High-throughput

0.479

High

1146710

PCBP1
Poly(rC)-binding protein 1

1

5

Small-scale

0.479

High

1197513

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

10

High-throughput

0.479

High

1197626

MIDN
Midnolin

1

3

High-throughput

0.479

High

1218586

OTU1
Ubiquitin thioesterase OTU1

1

3

High-throughput

0.479

High

1246844

RICTR
Rapamycin-insensitive companion of mTOR

1

4

High-throughput

0.479

High

1250727

SLN11
Schlafen family member 11

1

5

Small-scale

0.479

High

1250746

ASB11
Ankyrin repeat and SOCS box protein 11

1

12

High-throughput

0.479

High

1250751

CHM4C
Charged multivesicular body protein 4c

1

9

High-throughput

0.479

High

1250774

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.479

High

1250775

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1250780

DNJC5
DnaJ homolog subfamily C member 5

1

13

High-throughput

0.479

High

1250781

CHM4B
Charged multivesicular body protein 4b

1

9

High-throughput

0.479

High

1250787

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.479

High

1250792

RNF12
E3 ubiquitin-protein ligase RLIM

1

10

High-throughput

0.479

High

1250795

HDAC6
Protein deacetylase HDAC6

1

17

High-throughput

0.479

High

1250797

SEPT9
Septin-9

1

4

Small-scale

0.479

High

567429

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

1250790

DISC1
Disrupted in schizophrenia 1 protein

1

5

High-throughput

0.457

High

529983

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.445

High

765639

BMI1
Polycomb complex protein BMI-1

1

12

High-throughput

0.445

High

839037

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

11

High-throughput

0.445

High

1031809

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.445

High

1156671

NF2L2
Nuclear factor erythroid 2-related factor 2

1

5

High-throughput

0.445

High

1250757

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.445

High

1250760

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

13

High-throughput

0.445

High

344549

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

1

High-throughput

0.439

High

1250733

PIAS4
E3 SUMO-protein ligase PIAS4

1

4

High-throughput

0.439

High

1250758

YTDC1
YTH domain-containing protein 1

1

4

High-throughput

0.439

High

247970

NUPR1
Nuclear protein 1

1

3

High-throughput

0.437

High

293894

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

331067

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.437

High

378125

TNFA
Tumor necrosis factor

1

3

High-throughput

0.437

High

472833

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

High-throughput

0.437

High

474077

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.437

High

588975

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

657609

GCSP
Glycine dehydrogenase

1

5

High-throughput

0.437

High

693333

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

10

High-throughput

0.437

High

768482

RFA3
Replication protein A 14 kDa subunit

1

10

High-throughput

0.437

High

1031423

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

1241890

FBX42
F-box only protein 42

1

11

High-throughput

0.437

High

1250159

LRC31
Leucine-rich repeat-containing protein 31

1

8

High-throughput

0.437

High

1250724

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1250728

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

1250735

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.437

High

1250738

TRI58
E3 ubiquitin-protein ligase TRIM58

1

9

Small-scale

0.437

High

1250740

FBX25
F-box only protein 25

1

9

High-throughput

0.437

High

1250741

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.437

High

1250744

RN138
E3 ubiquitin-protein ligase RNF138

1

15

High-throughput

0.437

High

1250748

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1250771

ACE2
Angiotensin-converting enzyme 2

1

6

High-throughput

0.437

High

1250777

RNF38
E3 ubiquitin-protein ligase RNF38

1

9

Small-scale

0.437

High

1250791

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.437

High

1250730

FBX11
F-box only protein 11

1

0

High-throughput

0.426

High

255083

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

9

High-throughput

0.407

High

516539

CALM3
Calmodulin-3

1

2

High-throughput

0.407

High

1103241

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.407

High

1167065

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

2

High-throughput

0.407

High

1250725

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

6

High-throughput

0.407

High

1250739

MFSD8
Major facilitator superfamily domain-containing protein 8

1

3

High-throughput

0.407

High

1250743

S38A5
Sodium-coupled neutral amino acid transporter 5

1

2

High-throughput

0.407

High

1250759

MIA2
Melanoma inhibitory activity protein 2

1

20

High-throughput

0.407

High

1250762

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

18

High-throughput

0.407

High

1250764

ZBT18
Zinc finger and BTB domain-containing protein 18

1

9

High-throughput

0.407

High

1250773

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.407

High

1250805

NAC2
Sodium/calcium exchanger 2

1

5

High-throughput

0.407

High

1250754

SGF29
SAGA-associated factor 29

3

0

High-throughput

0.347

High

169189

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

488813

FURIN
Furin

1

0

High-throughput

0.279

Low

515887

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

1250731

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

1250768

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.279

Low

1250800

MUCEN
Endomucin

1

0

High-throughput

0.279

Low

130139

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.249

Low

580651

AMPN
Aminopeptidase N

1

0

High-throughput

0.249

Low

1041669

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low

1250783

ARMC7
Armadillo repeat-containing protein 7

1

0

High-throughput

0.249

Low

1250803

POLI
DNA polymerase iota

1

0

Small-scale

0.249

Low

635891

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025