Protein: PRSS8
Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain]

Gene: PRSS8
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q16651

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

212408

SPIT2
Kunitz-type protease inhibitor 2

1

12

High-throughput

0.691

High

634761

GRAH
Granzyme H

1

14

High-throughput

0.691

High

664048

PRTN3
Myeloblastin

1

12

High-throughput

0.691

High

1160909

MICA
MHC class I polypeptide-related sequence A

1

12

High-throughput

0.691

High

1160930

KLK15
Kallikrein-15

1

13

High-throughput

0.691

High

1160936

KLK5
Kallikrein-5

1

8

High-throughput

0.691

High

1160934

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

3

High-throughput

0.618

High

396209

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

139219

UPK2
Uroplakin-2

1

2

High-throughput

0.536

High

182548

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

231312

EFNA2
Ephrin-A2

1

4

High-throughput

0.536

High

335388

GDF11
Growth/differentiation factor 11

1

6

High-throughput

0.536

High

408075

TBB4A
Tubulin beta-4A chain

1

15

High-throughput

0.536

High

488800

FURIN
Furin

1

1

High-throughput

0.536

High

506847

CFC1
Cryptic protein

1

1

High-throughput

0.536

High

548020

PSPC
Surfactant protein C

1

3

High-throughput

0.536

High

834460

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.536

High

848026

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

2

High-throughput

0.536

High

896387

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.536

High

1085945

HYAL1
Hyaluronidase-1

1

1

High-throughput

0.536

High

1089099

HYAL2
Hyaluronidase-2

1

1

High-throughput

0.536

High

1160914

I27RA
Interleukin-27 receptor subunit alpha

1

9

High-throughput

0.536

High

1160916

LYZL2
Lysozyme-like protein 2

1

1

High-throughput

0.536

High

1160919

FNDC5
Fibronectin type III domain-containing protein 5

1

5

High-throughput

0.536

High

1160920

CLC2B
C-type lectin domain family 2 member B

1

5

High-throughput

0.536

High

1160927

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

1160933

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.536

High

260869

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

570674

EDN3
Endothelin-3

1

0

High-throughput

0.513

High

1159198

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

1160917

TRML1
Trem-like transcript 1 protein

1

0

High-throughput

0.513

High

1160923

LEAP2
Liver-expressed antimicrobial peptide 2

1

0

High-throughput

0.513

High

1160929

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

0

High-throughput

0.513

High

1160931

PIGU
GPI-anchor transamidase component PIGU

1

0

High-throughput

0.513

High

62123

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

5

High-throughput

0.489

High

552257

ADT3
ADP/ATP translocase 3

1

8

High-throughput

0.489

High

996712

TBA1B
Tubulin alpha-1B chain

1

12

High-throughput

0.489

High

1099687

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.489

High

1160912

KMCP1
Kidney mitochondrial carrier protein 1

1

10

High-throughput

0.489

High

1160924

KLH15
Kelch-like protein 15

1

2

High-throughput

0.489

High

1160925

RBM14
RNA-binding protein 14

1

1

High-throughput

0.489

High

1160935

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

578495

BRAF
Serine/threonine-protein kinase B-raf

1

2

High-throughput

0.479

High

1160928

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.460

High

1160913

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

840719

RS27
Small ribosomal subunit protein eS27

1

1

High-throughput

0.437

High

1160921

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

212573

GPAA1
GPI-anchor transamidase component GPAA1

1

0

High-throughput

0.279

Low

223726

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.279

Low

355363

B3GT4
Beta-1,3-galactosyltransferase 4

1

0

High-throughput

0.279

Low

1006249

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.279

Low

1160910

AGK
Acylglycerol kinase, mitochondrial

1

0

High-throughput

0.279

Low

1160911

DYLT4
Dynein light chain Tctex-type 4

1

0

High-throughput

0.279

Low

1160918

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.279

Low

1160922

TF2H4
General transcription factor IIH subunit 4

1

0

High-throughput

0.279

Low

1160926

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

1

0

High-throughput

0.279

Low

1160932

ANLN
Anillin

1

0

High-throughput

0.279

Low

1160915

MCAF1
Activating transcription factor 7-interacting protein 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025