HitPredict

Interactor 1: KCNG3 (Q8TAE7)
Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv10.1) (Voltage-gated potassium channel subunit Kv6.3)
Gene: KCNG3

Interactor 2: KCNB2 (Q92953)
Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)
Gene: KCNB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	19074135
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BTB_2~BTB_2, Ion_trans~Ion_trans
Common GO terms	GO:0005251 - delayed rectifier potassium channel activity GO:0005886 - plasma membrane GO:0008076 - voltage-gated potassium channel complex GO:0051260 - protein homooligomerization GO:0071805 - potassium ion transmembrane transport
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 436 Hs			1 911
+	Hs
		1273152 KCNB2_HUMAN (3-434): 1.67e-138: 420: 37.50		KCNB2_HUMAN (1-911): 0: 738: 100.00
+	Hs
		1058645 KCNB2_HUMAN (3-434): 1.67e-138: 420: 37.50		KCNB1_HUMAN (6-911): 0: 616: 62.06
+	Hs
		1058633 KCNB1_HUMAN (3-434): 3.45e-138: 418: 37.04		KCNB1_HUMAN (6-911): 0: 616: 62.06
+	Mm
		61654 KCNB2_MOUSE (3-434): 1.31e-138: 421: 37.73		KCNB1_MOUSE (6-911): 0: 608: 61.40
+	Hs
		569033 KCNA3_HUMAN (6-427): 3.86e-122: 368: 29.49		KCNA6_HUMAN (35-433): 2.12e-164: 492: 34.35
+	Hs
		1273155 KCNB2_HUMAN (3-434): 1.67e-138: 420: 37.50		KCNS3_HUMAN (29-503): 7.52e-130: 401: 41.27
+	Hs
		1058647 KCNB1_HUMAN (3-434): 3.45e-138: 418: 37.04		KCNS3_HUMAN (29-503): 7.52e-130: 401: 41.27
+	Hs
		1273157 KCNB2_HUMAN (3-434): 1.67e-138: 420: 37.50		KCNF1_HUMAN (22-502): 5.5e-128: 396: 37.73
+	Hs
		1273162 KCNB2_HUMAN (3-434): 1.67e-138: 420: 37.50		KCNG1_HUMAN (2-440): 2.6e-123: 385: 40.31
+	Hs
		1058649 KCNB1_HUMAN (3-434): 3.45e-138: 418: 37.04		KCNG1_HUMAN (2-440): 2.6e-123: 385: 40.31
+	Hs
		1255150 KCNB2_HUMAN (3-434): 1.67e-138: 420: 37.50		KCNG4_HUMAN (1-484): 6.61e-117: 368: 36.82
+	Hs
		1058643 KCNB1_HUMAN (3-434): 3.45e-138: 418: 37.04		KCNG4_HUMAN (1-484): 6.61e-117: 368: 36.82
+	Hs
		1058644 KCNB1_HUMAN (3-434): 3.45e-138: 418: 37.04		KCNV2_HUMAN (17-438): 1.3e-111: 355: 39.22
+	Hs
		1161871 KCNB2_HUMAN (3-434): 1.67e-138: 420: 37.50		KCNV1_HUMAN (25-467): 2.1e-108: 345: 42.95
+	Hs
		558708 KCNA3_HUMAN (6-427): 3.86e-122: 368: 29.49		KCNA2_HUMAN (5-480): 4.04e-128: 397: 32.87
+	Hs
		1058636 KCNB1_HUMAN (3-434): 3.45e-138: 418: 37.04		KCNV1_HUMAN (25-467): 2.1e-108: 345: 42.95
+	Hs
		1058642 KCNB1_HUMAN (3-434): 3.45e-138: 418: 37.04		KCNG3_HUMAN (37-441): 6.64e-92: 299: 39.01
+	Hs
		1058651 KCNB1_HUMAN (3-434): 3.45e-138: 418: 37.04		KCNG2_HUMAN (32-432): 1.52e-87: 288: 39.61