Protein: MCE1
mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]

Gene: MCE1, RNGTT
Organism: Homo sapiens
Interactions: 140
UniProt ID: O60942

Gene Ontology (top 5):
GO:0004484 - mRNA guanylyltransferase activity
GO:0004651 - polynucleotide 5'-phosphatase activity
GO:0004721 - phosphoprotein phosphatase activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

192763

RPB4
DNA-directed RNA polymerase II subunit RPB4

4

1

High-throughput

0.895

High

262506

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

1

High-throughput

0.847

High

262480

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

7

High-throughput

0.789

High

262577

NUP50
Nuclear pore complex protein Nup50

4

2

High-throughput

0.694

High

130325

SPT5H
Transcription elongation factor SPT5

4

3

High-throughput

0.686

High

262477

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

2

High-throughput

0.686

High

262496

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.656

High

262478

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

2

High-throughput

0.656

High

262482

RPB2
DNA-directed RNA polymerase II subunit RPB2

3

5

High-throughput

0.656

High

262503

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

3

4

High-throughput

0.656

High

262527

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

3

1

High-throughput

0.656

High

262486

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

2

High-throughput

0.650

High

262574

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

3

0

High-throughput

0.628

High

262454

MCE1
mRNA-capping enzyme

1

17

High-throughput

0.618

High

262479

CSK22
Casein kinase II subunit alpha'

1

13

High-throughput

0.618

High

262510

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.618

High

262532

SPT6H
Transcription elongation factor SPT6

1

4

High-throughput

0.618

High

262547

STYX
Serine/threonine/tyrosine-interacting protein

1

7

High-throughput

0.618

High

262561

BARD1
BRCA1-associated RING domain protein 1

1

10

High-throughput

0.618

High

262538

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.613

High

262522

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

2

1

High-throughput

0.611

High

262551

APBP2
Amyloid protein-binding protein 2

2

1

High-throughput

0.606

High

262481

EF1D
Elongation factor 1-delta

2

0

High-throughput

0.602

High

262498

IMA5
Importin subunit alpha-5

2

4

High-throughput

0.601

High

262497

IMA1
Importin subunit alpha-1

2

4

High-throughput

0.588

High

262461

RECQ5
ATP-dependent DNA helicase Q5

2

3

High-throughput

0.584

High

262508

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

2

High-throughput

0.584

High

262509

SPT4H
Transcription elongation factor SPT4

2

1

High-throughput

0.584

High

262468

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

262520

DUS28
Dual specificity phosphatase 28

1

7

High-throughput

0.553

High

262530

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.553

High

262543

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.553

High

262579

HECD1
E3 ubiquitin-protein ligase HECTD1

1

15

High-throughput

0.553

High

142461

IMA3
Importin subunit alpha-3

1

4

High-throughput

0.536

High

179012

IMA6
Importin subunit alpha-6

1

4

High-throughput

0.536

High

262466

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.536

High

262490

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

262493

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.536

High

262507

RAN
GTP-binding nuclear protein Ran

1

3

High-throughput

0.536

High

262517

IMB1
Importin subunit beta-1

1

12

High-throughput

0.536

High

262519

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

High-throughput

0.536

High

262554

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

262582

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

3

High-throughput

0.536

High

262494

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.527

High

262563

SH3G3
Endophilin-A3

2

3

High-throughput

0.521

High

207721

MCES
mRNA cap guanine-N(7) methyltransferase

1

1

Small-scale

0.501

High

262467

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

142746

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

190757

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

240252

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

245040

AQR
RNA helicase aquarius

1

3

High-throughput

0.479

High

262455

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

5

High-throughput

0.479

High

262458

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

262460

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

262462

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

2

High-throughput

0.479

High

262463

SCAF4
SR-related and CTD-associated factor 4

1

2

High-throughput

0.479

High

262465

HERC2
E3 ubiquitin-protein ligase HERC2

1

13

High-throughput

0.479

High

262469

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

262470

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

262471

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

262473

NFIC
Nuclear factor 1 C-type

1

6

High-throughput

0.479

High

262475

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

262476

NCK1
SH2/SH3 adapter protein NCK1

1

6

Small-scale

0.479

High

262483

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

2

High-throughput

0.479

High

262484

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

262487

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

262488

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

262489

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

7

High-throughput

0.479

High

262491

CRK
Adapter molecule crk

1

6

High-throughput

0.479

High

262495

MCM2
DNA replication licensing factor MCM2

1

9

High-throughput

0.479

High

262499

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

2

High-throughput

0.479

High

262500

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

2

High-throughput

0.479

High

262501

BLM
RecQ-like DNA helicase BLM

1

5

High-throughput

0.479

High

262511

NOP14
Nucleolar protein 14

1

1

High-throughput

0.479

High

262512

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

262513

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

262514

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

262516

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

262523

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

5

High-throughput

0.479

High

262534

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

262535

AROS
Active regulator of SIRT1

1

3

High-throughput

0.479

High

262540

ARL14
ADP-ribosylation factor-like protein 14

1

3

High-throughput

0.479

High

262541

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.479

High

262542

ARL10
ADP-ribosylation factor-like protein 10

1

5

High-throughput

0.479

High

262545

G45IP
Large ribosomal subunit protein mL64

1

3

High-throughput

0.479

High

262550

RTF1
RNA polymerase-associated protein RTF1 homolog

1

1

High-throughput

0.479

High

262552

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

262553

RL36L
Ribosomal protein eL42-like

1

3

High-throughput

0.479

High

262555

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

262558

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

262559

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

3

High-throughput

0.479

High

262566

SETD2
Histone-lysine N-methyltransferase SETD2

1

6

High-throughput

0.479

High

262571

SFR19
Splicing factor, arginine/serine-rich 19

1

4

High-throughput

0.479

High

262576

XPO7
Exportin-7

1

13

High-throughput

0.479

High

262580

FZR1
Fizzy-related protein homolog

1

10

High-throughput

0.479

High

262581

SRRM2
Serine/arginine repetitive matrix protein 2

1

4

High-throughput

0.479

High

262459

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.458

High

262464

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.458

High

262504

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

262505

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

262528

CDC73
Parafibromin

1

0

High-throughput

0.458

High

262539

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

262564

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

High-throughput

0.458

High

262568

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.458

High

262569

NELFA
Negative elongation factor A

1

0

High-throughput

0.458

High

262573

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.458

High

262472

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

262485

FUS
RNA-binding protein FUS

1

2

High-throughput

0.445

High

262549

S39A7
Zinc transporter SLC39A7

1

4

High-throughput

0.445

High

262456

CLU
Clustered mitochondria protein homolog

1

4

High-throughput

0.437

High

262502

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.437

High

262524

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.437

High

262544

LY65B
Lymphocyte antigen 6 complex locus protein G5b

1

1

High-throughput

0.437

High

262546

BRX1
Ribosome biogenesis protein BRX1 homolog

1

2

High-throughput

0.437

High

262548

POF1B
Protein POF1B

1

2

High-throughput

0.437

High

262556

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

High-throughput

0.437

High

262557

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

262560

SNX18
Sorting nexin-18

1

4

High-throughput

0.437

High

262570

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

262575

PHRF1
PHD and RING finger domain-containing protein 1

1

6

High-throughput

0.437

High

262583

SNX9
Sorting nexin-9

1

3

High-throughput

0.437

High

262521

S39AC
Zinc transporter ZIP12

1

4

High-throughput

0.407

High

262525

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.407

High

262529

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.407

High

262533

SV2A
Synaptic vesicle glycoprotein 2A

1

2

High-throughput

0.407

High

262536

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

1

High-throughput

0.407

High

262537

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.407

High

262572

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

1

High-throughput

0.407

High

262492

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

262578

INTU
Protein inturned

1

0

High-throughput

0.279

Low

262457

SG2A1
Mammaglobin-B

1

0

High-throughput

0.249

Low

262515

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.249

Low

262518

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.249

Low

262526

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

262531

NOL8
Nucleolar protein 8

1

0

High-throughput

0.249

Low

262562

PROL1
Opiorphin prepropeptide

1

0

High-throughput

0.249

Low

262567

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.249

Low

262474

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low

262565

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025