HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: UBP5 (P45974)
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)
Gene: USP5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	31048545, 35331737
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 858
+	Hs
		800615 ITCH_HUMAN (1-870): 0: 902: 54.26		UBP5_HUMAN (1-858): 0: 842: 100.00
+	Hs
		1273570 ITCH_HUMAN (1-870): 0: 902: 54.26		UBP13_HUMAN (2-858): 0: 721: 59.47
+	Hs
		125624 WWP2_HUMAN (1-870): 0: 982: 100.00		USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20
+	Hs
		125625 WWP2_HUMAN (1-870): 0: 982: 100.00		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Hs
		1273700 ITCH_HUMAN (1-870): 0: 902: 54.26		USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20
+	Hs
		1273724 WWP1_HUMAN (1-870): 0: 888: 58.38		USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20
+	Hs
		64219 ITCH_HUMAN (1-870): 0: 902: 54.26		UBP27_HUMAN (262-682): 6.68e-84: 277: 14.69
+	Hs
		259303 ITCH_HUMAN (1-870): 0: 902: 54.26		UBP12_HUMAN (325-683): 3.4e-80: 264: 16.94
+	Hs
		1273807 NED4L_HUMAN (5-867): 0: 785: 32.17		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Hs
		808303 NEDD4_HUMAN (90-867): 0: 731: 35.94		UBP36_HUMAN (250-817): 9.73e-85: 295: 13.61
+	Hs
		800630 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		UBP5_HUMAN (1-858): 0: 842: 100.00
+	Mm
		880550 SMUF1_MOUSE (1-473): 4.64e-40: 160: 14.46		UBP5_MOUSE (1-858): 0: 844: 98.37
+	Hs
		1192153 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20
+	Hs
		1192154 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Hs
		1173813 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBP49_HUMAN (177-293): 1.05e-15: 83.7: 26.50
+	Hs
		1273741 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20
+	Mm
		292021 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		UBP2_MOUSE (241-660): 5.04e-72: 250: 15.70
+	Hs
		1273751 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20
+	Hs
		1176343 HECW1_HUMAN (187-523): 3.02e-13: 76.4: 19.58		UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17
+	Hs
		1350500 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		UBP21_HUMAN (319-594): 6.55e-24: 109: 22.37