HitPredict

Interactor 1: NEK9 (Q8TD19)
Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)
Gene: NEK9

Interactor 2: NEK7 (Q8TDX7)
Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)
Gene: NEK7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.934

The method score is based on:

Property Details
Experiments 27173435, 33961781, 32707033, 12840024, 20562859
Identification Methods affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, tandem affinity purification, pull down
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005813 - centrosome
GO:0007346 - regulation of mitotic cell cycle
and 2 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 979
Hs

1 302
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024