Protein: TRIM4
E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4)

Gene: TRIM4
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q9C037

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1292745

TRI69
E3 ubiquitin-protein ligase TRIM69

2

16

High-throughput

0.811

High

1420583

TRIM4
E3 ubiquitin-protein ligase TRIM4

2

18

Small-scale

0.768

High

1357746

TRI41
E3 ubiquitin-protein ligase TRIM41

1

20

High-throughput

0.698

High

1116353

RAB31
Ras-related protein Rab-31

4

6

High-throughput

0.691

High

787583

TNR3
Tumor necrosis factor receptor superfamily member 3

3

3

High-throughput

0.667

High

452393

PDIA1
Protein disulfide-isomerase

3

5

High-throughput

0.657

High

1387191

RB39B
Ras-related protein Rab-39B

2

4

High-throughput

0.628

High

1255430

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1420592

TRI33
E3 ubiquitin-protein ligase TRIM33

1

19

High-throughput

0.618

High

669063

FPR2
N-formyl peptide receptor 2

2

0

High-throughput

0.602

High

1275787

TRPM8
Transient receptor potential cation channel subfamily M member 8

1

2

Small-scale

0.561

High

1155736

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.553

High

1028382

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

High-throughput

0.541

High

1384122

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.536

High

1417867

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.536

High

1420593

TRAK1
Trafficking kinesin-binding protein 1

1

11

High-throughput

0.536

High

920714

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

0

High-throughput

0.513

High

1420594

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.513

High

157821

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

223312

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

331300

KI20A
Kinesin-like protein KIF20A

1

19

High-throughput

0.479

High

476809

RSSA
Small ribosomal subunit protein uS2

1

2

Small-scale

0.479

High

647649

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

Small-scale

0.479

High

658387

RS3
Small ribosomal subunit protein uS3

1

4

Small-scale

0.479

High

691404

1433T
14-3-3 protein theta

1

12

Small-scale

0.479

High

1029378

SET
Protein SET

1

2

Small-scale

0.479

High

1057252

PRDX1
Peroxiredoxin-1

1

6

Small-scale

0.479

High

1107184

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1114230

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1137510

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1140811

KIF14
Kinesin-like protein KIF14

1

16

High-throughput

0.479

High

1229674

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1287013

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

20

Small-scale

0.479

High

1351969

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.479

High

1380421

ABTB1
Ankyrin repeat and BTB/POZ domain-containing protein 1

1

6

Small-scale

0.479

High

1385856

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

1420584

WWTR1
WW domain-containing transcription regulator protein 1

1

5

High-throughput

0.479

High

1420585

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

1420587

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1420588

ECT2
Protein ECT2

1

4

High-throughput

0.479

High

1420590

ANLN
Anillin

1

3

High-throughput

0.479

High

1420591

UBQL2
Ubiquilin-2

1

11

High-throughput

0.479

High

246924

KDM1A
Lysine-specific histone demethylase 1A

1

3

Small-scale

0.437

High

260420

BRD4
Bromodomain-containing protein 4

1

4

Small-scale

0.437

High

1239476

H3C
Histone H3.3C

1

4

Small-scale

0.437

High

1420586

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.437

High

1397976

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.407

High

887204

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.373

High

261552

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

1420589

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.279

Low

353547

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

1197278

MBRL
Membralin

1

0

Small-scale

0.249

Low

841247

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025