HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: ARRD1 (Q8N5I2)
Arrestin domain-containing protein 1 (Alpha-arrestin 1)
Gene: ARRDC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	26186194, 21516116, 28514442, 31048545, 33961781, 22315426, 32296183, 38270169, 21191027, 23236378, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006858 - extracellular transport GO:0016567 - protein ubiquitination GO:0045746 - negative regulation of Notch signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 433
+	Hs
		1234600 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRD1_HUMAN (1-433): 5.38e-131: 386: 100.00
+	Hs
		125595 WWP2_HUMAN (1-870): 0: 982: 100.00		ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36
+	Hs
		1234607 WWP1_HUMAN (1-870): 0: 888: 58.38		ARRD1_HUMAN (1-433): 5.38e-131: 386: 100.00
+	Hs
		125633 WWP2_HUMAN (1-870): 0: 982: 100.00		ARRD3_HUMAN (1-373): 1.85e-94: 292: 20.81
+	Hs
		125707 WWP2_HUMAN (1-870): 0: 982: 100.00		TXNIP_HUMAN (3-360): 7.93e-86: 269: 21.09
+	Hs
		125586 WWP2_HUMAN (1-870): 0: 982: 100.00		ARRD4_HUMAN (2-361): 1.4e-82: 261: 24.07
+	Hs
		1252807 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36
+	Hs
		1285047 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRD3_HUMAN (1-373): 1.85e-94: 292: 20.81
+	Hs
		1252814 WWP1_HUMAN (1-870): 0: 888: 58.38		ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36
+	Hs
		1285070 WWP1_HUMAN (1-870): 0: 888: 58.38		ARRD3_HUMAN (1-373): 1.85e-94: 292: 20.81
+	Hs
		1294858 ITCH_HUMAN (1-870): 0: 902: 54.26		TXNIP_HUMAN (3-360): 7.93e-86: 269: 21.09
+	Dm
		1367634 SUDX_DROME (14-870): 0: 852: 52.14		Q9VI00_DROME (5-389): 3.03e-102: 312: 19.62
+	Hs
		1241904 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRD4_HUMAN (2-361): 1.4e-82: 261: 24.07
+	Hs
		1327911 WWP1_HUMAN (1-870): 0: 888: 58.38		TXNIP_HUMAN (3-360): 7.93e-86: 269: 21.09
+	Hs
		1241917 WWP1_HUMAN (1-870): 0: 888: 58.38		ARRD4_HUMAN (2-361): 1.4e-82: 261: 24.07
+	Hs
		686035 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRB2_HUMAN (22-320): 9.21e-72: 233: 16.62
+	Hs
		827260 ITCH_HUMAN (1-870): 0: 902: 54.26		ARRB1_HUMAN (22-339): 5.08e-70: 229: 15.29
+	Mm
		1208049 ITCH_MOUSE (1-870): 0: 892: 55.81		ARRB2_MOUSE (22-320): 2.4e-69: 227: 16.29
+	Dm
		1367613 SUDX_DROME (14-870): 0: 852: 52.14		Q9VHZ7_DROME (7-293): 5.87e-81: 260: 23.30
+	Dm
		1366476 SUDX_DROME (14-870): 0: 852: 52.14		Q9VGU4_DROME (6-421): 1.2e-75: 246: 20.05