HitPredict

Interactor 1: CAST1 (Q8WTX7)
Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3)
Gene: CASTOR1

Interactor 2: WDR24 (Q96S15)
GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24)
Gene: WDR24

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	35831510, 26186194, 26972053, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0034198 - cellular response to amino acid starvation GO:1904262 - negative regulation of TORC1 signaling GO:1904263 - positive regulation of TORC1 signaling
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 329 Hs			1 790
+	Hs
		63021 CAST2_HUMAN (1-324): 0: 561: 63.50		WDR24_HUMAN (1-790): 0: 594: 100.00
+	Hs
		1162288 CAST1_HUMAN (1-329): 0: 582: 100.00		WDR59_HUMAN (159-345): 6.31e-21: 100: 20.31
+	Hs
		1259683 CAST1_HUMAN (1-329): 0: 582: 100.00		MIOS_HUMAN (2-326): 4.54e-17: 87.9: 13.22
+	Hs
		63018 CAST2_HUMAN (1-324): 0: 561: 63.50		WDR59_HUMAN (159-345): 6.31e-21: 100: 20.31
+	Hs
		63022 CAST2_HUMAN (1-324): 0: 561: 63.50		MIOS_HUMAN (2-326): 4.54e-17: 87.9: 13.22