Protein: RIPK3
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)

Gene: RIPK3
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q9Y572

Gene Ontology (top 5):
GO:0001914 - regulation of T cell mediated cytotoxicity
GO:0002819 - regulation of adaptive immune response
GO:0003713 - transcription coactivator activity
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1109691

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

25

20

Small-scale

0.992

High

1333002

MLKL
Mixed lineage kinase domain-like protein

9

18

Small-scale

0.963

High

1096946

FADD
FAS-associated death domain protein

7

18

Small-scale

0.949

High

1132473

CASP8
Caspase-8

5

7

Small-scale

0.902

High

1491494

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

4

18

Small-scale

0.900

High

1430851

ZBP1
Z-DNA-binding protein 1

4

3

Small-scale

0.878

High

932159

EPHA4
Ephrin type-A receptor 4

3

19

High-throughput

0.861

High

1158625

CDC37
Hsp90 co-chaperone Cdc37

2

5

High-throughput

0.776

High

1107376

BIRC3
Baculoviral IAP repeat-containing protein 3

1

17

Small-scale

0.761

High

1107515

BIRC2
Baculoviral IAP repeat-containing protein 2

1

20

Small-scale

0.761

High

1022818

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

Small-scale

0.681

High

1038734

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

15

High-throughput

0.665

High

1106149

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

15

High-throughput

0.665

High

1006827

SRPK2
SRSF protein kinase 2

1

7

High-throughput

0.647

High

171352

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

3

High-throughput

0.618

High

243404

PRKN
E3 ubiquitin-protein ligase parkin

1

7

Small-scale

0.618

High

462082

HS90A
Heat shock protein HSP 90-alpha

1

17

High-throughput

0.618

High

468953

HS90B
Heat shock protein HSP 90-beta

1

17

High-throughput

0.618

High

485540

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.618

High

507438

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

6

High-throughput

0.618

High

618752

ML12A
Myosin regulatory light chain 12A

1

14

High-throughput

0.618

High

728032

DNJA1
DnaJ homolog subfamily A member 1

1

14

High-throughput

0.618

High

729509

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.618

High

920541

DAPK1
Death-associated protein kinase 1

1

10

High-throughput

0.618

High

993399

ACTG
Actin, cytoplasmic 2

1

4

High-throughput

0.618

High

1117540

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

4

High-throughput

0.618

High

1144689

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

2

High-throughput

0.618

High

1250807

MPRIP
Myosin phosphatase Rho-interacting protein

1

4

High-throughput

0.618

High

1307156

TCAM1
TIR domain-containing adapter molecule 1

1

4

Small-scale

0.618

High

1453803

RAI14
Ankycorbin

1

11

High-throughput

0.618

High

600576

ZSC20
Zinc finger and SCAN domain-containing protein 20

1

0

Small-scale

0.614

High

1144511

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.586

High

378214

TNFA
Tumor necrosis factor

2

4

Small-scale

0.584

High

1390449

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

2

Small-scale

0.578

High

1459020

DAXX
Death domain-associated protein 6

1

2

Small-scale

0.578

High

1125276

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

8

Small-scale

0.561

High

1491427

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.561

High

425867

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

5

High-throughput

0.536

High

1207027

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

2

High-throughput

0.536

High

1393524

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

1

Small-scale

0.536

High

1450922

RNF12
E3 ubiquitin-protein ligase RLIM

1

6

High-throughput

0.536

High

1491495

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

4

High-throughput

0.536

High

1301015

RFX6
DNA-binding protein RFX6

1

0

High-throughput

0.518

High

254248

CTND1
Catenin delta-1

1

2

High-throughput

0.515

High

731740

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.515

High

1396163

LRAT2
Protein LRATD2

1

0

High-throughput

0.513

High

1449852

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.513

High

517277

AMY1B
Alpha-amylase 1B

2

1

High-throughput

0.504

High

251830

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

2

Small-scale

0.501

High

595662

H15
Histone H1.5

1

3

Small-scale

0.501

High

1046676

GLGB
1,4-alpha-glucan-branching enzyme

1

1

Small-scale

0.501

High

1325624

TXND3
Thioredoxin domain-containing protein 3

1

2

Small-scale

0.501

High

1351256

HELQ
Helicase POLQ-like

1

2

Small-scale

0.501

High

1389828

HBAP1
HSPB1-associated protein 1

1

5

Small-scale

0.501

High

1435987

TLE6
Transducin-like enhancer protein 6

1

7

Small-scale

0.501

High

446193

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.493

High

1413115

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.493

High

1491111

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

Small-scale

0.480

High

123889

MYO1C
Unconventional myosin-Ic

1

7

High-throughput

0.479

High

141720

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.479

High

224836

ACTN4
Alpha-actinin-4

1

1

High-throughput

0.479

High

228009

MYO1B
Unconventional myosin-Ib

1

9

High-throughput

0.479

High

318422

MYO1D
Unconventional myosin-Id

1

7

High-throughput

0.479

High

348815

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

408198

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.479

High

425085

ADT2
ADP/ATP translocase 2

1

10

High-throughput

0.479

High

447902

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.479

High

457800

TBB5
Tubulin beta chain

1

20

High-throughput

0.479

High

460675

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

475087

VIME
Vimentin

1

2

High-throughput

0.479

High

482985

TPM1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.479

High

535713

BIP
Endoplasmic reticulum chaperone BiP

1

16

High-throughput

0.479

High

538174

HSP7C
Heat shock cognate 71 kDa protein

1

12

High-throughput

0.479

High

574005

MYL6B
Myosin light chain 6B

1

12

High-throughput

0.479

High

608802

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

High-throughput

0.479

High

637809

FLNA
Filamin-A

1

2

High-throughput

0.479

High

697697

PYR1
Multifunctional protein CAD

1

3

High-throughput

0.479

High

715004

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.479

High

761549

HS71L
Heat shock 70 kDa protein 1-like

1

12

High-throughput

0.479

High

773315

MYH10
Myosin-10

1

2

High-throughput

0.479

High

786957

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.479

High

801599

HSPA9
Stress-70 protein, mitochondrial

1

18

High-throughput

0.479

High

840838

RS27
Small ribosomal subunit protein eS27

1

5

High-throughput

0.479

High

863046

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.479

High

876238

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.479

High

952682

MYL6
Myosin light polypeptide 6

1

12

High-throughput

0.479

High

968497

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.479

High

972179

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.479

High

982024

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

983622

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

High-throughput

0.479

High

984350

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

1007357

TCPB
T-complex protein 1 subunit beta

1

6

High-throughput

0.479

High

1008416

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

High-throughput

0.479

High

1010399

BASP1
Brain acid soluble protein 1

1

3

High-throughput

0.479

High

1024504

S25A3
Solute carrier family 25 member 3

1

12

High-throughput

0.479

High

1026299

CLH1
Clathrin heavy chain 1

1

3

High-throughput

0.479

High

1028921

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

4

High-throughput

0.479

High

1051896

EF1A2
Elongation factor 1-alpha 2

1

2

High-throughput

0.479

High

1057294

PRDX1
Peroxiredoxin-1

1

4

High-throughput

0.479

High

1090994

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1100583

TIF1B
Transcription intermediary factor 1-beta

1

2

Small-scale

0.479

High

1229888

CYTSA
Cytospin-A

1

6

High-throughput

0.479

High

1402538

NEB2
Neurabin-2

1

4

High-throughput

0.479

High

1407650

TCPH
T-complex protein 1 subunit eta

1

3

High-throughput

0.479

High

1410821

AIF1L
Allograft inflammatory factor 1-like

1

13

High-throughput

0.479

High

1415142

TBB2B
Tubulin beta-2B chain

1

20

High-throughput

0.479

High

1418712

TRI34
E3 ubiquitin-protein ligase TRIM34

1

6

Small-scale

0.479

High

1428711

SKI8
Superkiller complex protein 8

1

2

High-throughput

0.479

High

1437763

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

3

High-throughput

0.479

High

1450619

ATD3A
ATPase family AAA domain-containing protein 3A

1

15

High-throughput

0.479

High

1461773

COR1C
Coronin-1C

1

1

High-throughput

0.479

High

1461991

MYO6
Unconventional myosin-VI

1

4

High-throughput

0.479

High

1462715

Q9UQC1
Heat shock protein 72

1

15

High-throughput

0.479

High

1490462

RUVB2
RuvB-like 2

1

2

High-throughput

0.479

High

1490524

RUVB1
RuvB-like 1

1

2

High-throughput

0.479

High

1491356

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

1491496

SCIN
Scinderin

1

5

High-throughput

0.479

High

336256

TIAF1
Putative TGFB1-induced anti-apoptotic factor 1

1

0

High-throughput

0.458

High

476066

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

0

High-throughput

0.458

High

867557

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

915232

CAZA1
F-actin-capping protein subunit alpha-1

1

0

High-throughput

0.458

High

1058380

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1160811

DREB
Drebrin

1

0

High-throughput

0.458

High

1387183

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.458

High

1458433

GBG12

1

0

High-throughput

0.458

High

1459763

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.458

High

622720

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

10

Small-scale

0.437

High

829610

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.437

High

1192151

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

4

High-throughput

0.437

High

845168

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.279

Low

1460527

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.279

Low

1092423

IL24
Interleukin-24

1

0

Small-scale

0.261

Low

1179782

TMM44
Transmembrane protein 44

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025