Interactor 1: ODPX (O00330)
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)
Gene: PDHX
Interactor 2: DLDH (P09622)
Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)
Gene: DLD
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.90 | 1.00 | 0.950 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26186194, 28514442, 32296183, 33961781, 16442803, unassigned1304 |
| Identification Methods | affinity chromatography technology, two hybrid, isothermal titration calorimetry, x-ray crystallography, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | E3_binding~Pyr_redox_2, E3_binding~Pyr_redox_dim |
| Common GO terms | GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006086 - acetyl-CoA biosynthetic process from pyruvate GO:0045254 - pyruvate dehydrogenase complex |
| Homologous interactions | 12 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
