HitPredict

Interactor 1: ODPX (O00330)
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)
Gene: PDHX

Interactor 2: ODPB (P11177)
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)
Gene: PDHB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	26186194, 28514442, 7864652, 33961781
Identification Methods	affinity chromatography technology, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	E3_binding~Transketolase_C
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006086 - acetyl-CoA biosynthetic process from pyruvate GO:0045254 - pyruvate dehydrogenase complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 359
+	Ce
		218398 ODP2_CAEEL (15-500): 1.75e-147: 433: 33.46		ODPB_CAEEL (19-359): 1.15e-136: 394: 66.57
+	Hs
		505935 ODB2_HUMAN (1-500): 2.22e-155: 452: 24.56		ODBB_HUMAN (2-358): 1.28e-120: 355: 31.76
+	Mm
		1321930 ODO2_MOUSE (19-500): 4.08e-131: 389: 22.73		ODPB_MOUSE (1-359): 1.82e-145: 417: 93.59
+	Hs
		505781 ODO2_HUMAN (19-500): 2.29e-128: 382: 22.93		ODPB_HUMAN (1-359): 9.81e-148: 422: 100.00
+	Sc
		520802 ODP2_YEAST (26-500): 3.04e-143: 421: 30.91		ODPB_YEAST (19-359): 2.21e-129: 376: 59.65
+	Sc
		581273 ODO2_YEAST (48-500): 5.43e-121: 364: 23.36		ODPB_YEAST (19-359): 2.21e-129: 376: 59.65
+	Ss
		938316 P74510_SYNY3 (58-496): 1.79e-121: 364: 26.39		P73405_SYNY3 (35-358): 5e-122: 356: 41.98
+	Hs
		489688 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		ODPB_HUMAN (1-359): 9.81e-148: 422: 100.00