HitPredict

Interactor 1: APAF (Q7KLI1)
Apoptosome protein Dark (Death-associated APAF1-related killer) (Drosophila Apaf-1 related killer) (Homolog of Apaf-1 and ced-4)
Gene: Dark

Interactor 2: DRONC (Q9XYF4)
Caspase Dronc (EC 3.4.22.62) (Death regulator NEDD2-like caspase) [Cleaved into: Caspase Nc subunit 1; Caspase Nc subunit 2]
Gene: DRONC

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 0.60 0.646

The method score is based on:

Property Details
Experiments 21220123, 15710747, 20700104
Identification Methods cosedimentation through density gradient, 3D electron microscopy, two hybrid fragment pooling approach, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0006915 - apoptotic process
GO:0007291 - sperm individualization
GO:0012501 - programmed cell death
GO:0022416 - chaeta development
GO:0035006 - melanization defense response
and 5 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 1440
Dm

1 450
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025