Protein: CASP8
Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]

Gene: CASP8, Dredd
Organism: Drosophila melanogaster
Interactions: 73
UniProt ID: Q8IRY7

Gene Ontology (top 5):
GO:0002230 - positive regulation of defense response to virus by host
GO:0004197 - cysteine-type endopeptidase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1306755

CASP8
Caspase-8

3

19

Small-scale

0.834

High

1173321

DIAP2
Death-associated inhibitor of apoptosis 2

3

20

Small-scale

0.827

High

1306760

NFKB1
Nuclear factor NF-kappa-B p110 subunit

3

5

Small-scale

0.820

High

1306764

FADD
Fas-associated death domain protein

7

0

Small-scale

0.704

High

715340

HSP7A
Heat shock 70 kDa protein cognate 1

2

3

Small-scale

0.584

High

1266704

IMD
Protein immune deficiency

2

0

Small-scale

0.569

High

963854

SODC
Superoxide dismutase [Cu-Zn]

2

0

Small-scale

0.559

High

652052

ATC1
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

2

1

Small-scale

0.533

High

54521

TPR
Nucleoprotein TPR

1

3

High-throughput

0.481

High

1306761

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

1

High-throughput

0.481

High

121928

M9PGZ8
Smrter, isoform G

1

1

High-throughput

0.479

High

444086

TBA1
Tubulin alpha-1 chain

1

3

High-throughput

0.479

High

444145

TBA3
Tubulin alpha-3 chain

1

3

High-throughput

0.479

High

475810

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.479

High

534447

ACT1
Actin-5C

1

5

Small-scale

0.479

High

538250

HSP7D
Heat shock 70 kDa protein cognate 4

1

3

High-throughput

0.479

High

715361

BIP
Endoplasmic reticulum chaperone BiP

1

7

Small-scale

0.479

High

1174358

CP190
Centrosome-associated zinc finger protein Cp190

1

6

Small-scale

0.479

High

1174590

TBB1
Tubulin beta-1 chain

1

3

Small-scale

0.479

High

1264486

Q7K105
LD20892p

1

2

Small-scale

0.479

High

1306756

LVA
Protein lava lamp

1

3

High-throughput

0.479

High

1306757

Q8SWW8
RING-type E3 ubiquitin transferase

1

20

Small-scale

0.479

High

1306759

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

1

High-throughput

0.479

High

1306774

RAGP1
Ran GTPase-activating protein

1

13

Small-scale

0.479

High

1306776

SOYB
Putative ATP-dependent RNA helicase SoYb

1

3

High-throughput

0.479

High

1306791

RHGF
Rho GTPase-activating protein Graf

1

3

High-throughput

0.479

High

912368

UBC84
Ubiquitin-conjugating enzyme E2-18 kDa

1

1

High-throughput

0.464

High

1262299

Q7JVK8
GEO08987p1

1

0

High-throughput

0.458

High

1285535

Q86BB4
Transforming acidic coiled-coil protein, isoform E

1

0

High-throughput

0.458

High

1306762

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.458

High

1306766

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.458

High

1306770

MOC2B
Molybdopterin synthase catalytic subunit

1

0

High-throughput

0.458

High

1306773

SMD2
Probable small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

1306780

Q9VRL8
Blanks

1

0

High-throughput

0.458

High

1306787

Q9W2U7
LP18708p

1

0

High-throughput

0.458

High

1306779

Q9VPL9
FI24801p1

1

5

High-throughput

0.439

High

146124

CH60A
Heat shock protein 60A

1

2

High-throughput

0.437

High

898331

RL22
Large ribosomal subunit protein eL22

1

1

Small-scale

0.437

High

1013232

STIM
Stromal interaction molecule homolog

1

1

High-throughput

0.437

High

1175939

ADT
ADP,ATP carrier protein

1

2

High-throughput

0.437

High

1304038

SLE
Protein slender lobes

1

3

High-throughput

0.437

High

1306768

HCF
Host cell factor

1

3

High-throughput

0.437

High

1306771

SLEL
Slender lobes-like protein

1

1

High-throughput

0.437

High

1306777

CH60C
60 kDa heat shock protein homolog 2, mitochondrial

1

2

High-throughput

0.437

High

262883

TENM
Teneurin-m

1

0

High-throughput

0.426

High

1302778

Q8IGK6
RE72573p

1

2

High-throughput

0.417

High

1306763

Q9I7T8
PAN2-PAN3 deadenylation complex subunit PAN3

1

1

High-throughput

0.417

High

1306781

Q9VTJ5
GH09976p

1

5

High-throughput

0.417

High

1306784

Q9VZU6
BTB-VII protein domain

1

6

High-throughput

0.417

High

1306790

Q9Y1L3
Kismet

1

2

High-throughput

0.417

High

1267324

APAF
Apoptosome protein Dark

1

1

High-throughput

0.381

High

1306783

Q9VXQ5
Chaperonin containing TCP1 subunit 6

2

0

Small-scale

0.305

High

1306788

RS28
Small ribosomal subunit protein eS28

2

0

Small-scale

0.305

High

1306789

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.282

High

121565

M9PFI0
CCR4-NOT transcription complex subunit 4

1

0

High-throughput

0.249

Low

197792

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.249

Low

870606

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.249

Low

875229

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.249

Low

891978

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.249

Low

938910

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

1055713

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

1265785

Q7K3J0
T-complex protein 1 subunit theta

1

0

High-throughput

0.249

Low

1306758

Q8SYU0
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.249

Low

1306765

RUVB2
RuvB-like helicase 2

1

0

High-throughput

0.249

Low

1306767

Q9V406
Activator protein 4

1

0

High-throughput

0.249

Low

1306769

S39AD
Zinc transporter ZIP13 homolog

1

0

High-throughput

0.249

Low

1306772

Q9VHT6
Uncharacterized protein, isoform A

1

0

Small-scale

0.249

Low

1306775

Q9VJD1
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

1306778

Q9VP57
LD15904p

1

0

Small-scale

0.249

Low

1306782

Q9VV75
AT02348p

1

0

High-throughput

0.249

Low

1306785

Q9W1B9
Large ribosomal subunit protein uL11

1

0

Small-scale

0.249

Low

1306786

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025