HitPredict - High confidence protein-protein interactions

Interactor 1: XPF (Q92889)
DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)
Gene: ERCC4

Interactor 2: XPF (Q92889)
DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)
Gene: ERCC4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

Property	Details
Experiments	15932882, 17912758, 22483113
Identification Methods	pull down, x-ray crystallography, mass spectrometry studies of complexes, nuclear magnetic resonance
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	ERCC4~ERCC4
Common GO terms	GO:0000014 - single-stranded DNA endodeoxyribonuclease activity GO:0000109 - nucleotide-excision repair complex GO:0000110 - nucleotide-excision repair factor 1 complex GO:0000723 - telomere maintenance GO:0000712 - resolution of meiotic recombination intermediates and 24 others more... GO:0000724 - double-strand break repair via homologous recombination GO:0000736 - double-strand break repair via single-strand annealing, removal of nonhomologous ends GO:0000781 - chromosome, telomeric region GO:0001094 - TFIID-class transcription factor complex binding GO:0003684 - damaged DNA binding GO:0003697 - single-stranded DNA binding GO:0004520 - DNA endonuclease activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006289 - nucleotide-excision repair GO:0006303 - double-strand break repair via nonhomologous end joining GO:0009411 - response to UV GO:0009650 - UV protection GO:0010506 - regulation of autophagy GO:0032205 - negative regulation of telomere maintenance GO:0034644 - cellular response to UV GO:0061819 - telomeric DNA-containing double minutes formation GO:0070522 - ERCC4-ERCC1 complex GO:1901255 - nucleotide-excision repair involved in interstrand cross-link repair GO:1904357 - negative regulation of telomere maintenance via telomere lengthening GO:1905765 - negative regulation of protection from non-homologous end joining at telomere GO:1905768 - negative regulation of double-stranded telomeric DNA binding GO:1990841 - promoter-specific chromatin binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	916
Hs

1	916

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Last updated: 15 Jul 2024