Interactor 1: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Interactor 2: MED8 (Q96G25)
Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)
Gene: MED8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.84 0.60 0.714

The method score is based on:

Property Details
Experiments 24981860, 26496610, 27684187, 33961781, 20133760
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 4 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 2177
Hs

1 268
+ Hs

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Last updated: 15 Jul 2024