Protein: ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (OGDHC subunit E2) (Alpha-ketoglutarate dehydrogenase subunit E2) (alpha-KGDHC subunit E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex)

Gene: ODO2, KGD2
Organism: Saccharomyces cerevisiae S288C
Interactions: 109
UniProt ID: P19262

Gene Ontology (top 5):
GO:0004149 - dihydrolipoyllysine-residue succinyltransferase activity
GO:0005739 - mitochondrion
GO:0006099 - tricarboxylic acid cycle
GO:0006103 - 2-oxoglutarate metabolic process
GO:0033512 - L-lysine catabolic process to acetyl-CoA via saccharopine

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

619325

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

8

14

Small-scale

0.969

High

484716

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

7

16

Small-scale

0.748

High

619324

KGD4
Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial

5

0

Small-scale

0.691

High

554877

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

17

High-throughput

0.618

High

594873

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

13

High-throughput

0.618

High

510174

HSP77
Import motor subunit, mitochondrial

2

9

High-throughput

0.584

High

619343

HSP78
Heat shock protein 78, mitochondrial

2

3

High-throughput

0.584

High

453413

PYR1
Multifunctional protein URA2

1

5

High-throughput

0.575

High

619323

HSP60
Heat shock protein 60, mitochondrial

2

5

High-throughput

0.552

High

619342

UFD4
Ubiquitin fusion degradation protein 4

1

12

High-throughput

0.541

High

619359

IMB4
Importin subunit beta-4

2

3

High-throughput

0.537

High

619382

CLU
Clustered mitochondria protein 1

2

2

High-throughput

0.537

High

619322

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

17

Small-scale

0.527

High

619340

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.521

High

543761

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.504

High

619330

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

2

High-throughput

0.500

High

619378

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

2

High-throughput

0.500

High

619389

ADY3
Accumulates dyads protein 3

1

10

High-throughput

0.494

High

364918

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.489

High

569712

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.489

High

619358

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.489

High

416795

DNLI1
DNA ligase 1

1

0

High-throughput

0.479

High

514443

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

619331

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

3

High-throughput

0.479

High

619337

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

8

High-throughput

0.479

High

619339

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

1

High-throughput

0.479

High

619351

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

619356

TOM71
Protein TOM71

1

4

High-throughput

0.479

High

619357

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

1

High-throughput

0.479

High

619376

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

619384

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.479

High

619394

SMC6
Structural maintenance of chromosomes protein 6

1

4

High-throughput

0.479

High

619367

MTR4
ATP-dependent RNA helicase DOB1

1

1

High-throughput

0.470

High

619336

IMB3
Importin subunit beta-3

1

3

High-throughput

0.464

High

619393

SMT3
Ubiquitin-like protein SMT3

1

6

High-throughput

0.464

High

439082

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

619327

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.458

High

619360

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

619364

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

619370

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

619380

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

459011

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

557660

SRS2
ATP-dependent DNA helicase SRS2

1

2

High-throughput

0.457

High

574631

KSS1
Mitogen-activated protein kinase KSS1

1

2

High-throughput

0.457

High

619326

DBF2
Cell cycle protein kinase DBF2

1

4

High-throughput

0.457

High

619352

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

9

High-throughput

0.457

High

619353

SIF2
SIR4-interacting protein SIF2

1

4

High-throughput

0.457

High

619354

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.457

High

619362

RAD26
DNA repair and recombination protein RAD26

1

5

High-throughput

0.457

High

619363

PRK1
Actin-regulating kinase PRK1

1

1

High-throughput

0.457

High

619366

YFI6
Uncharacterized protein YFR016C

1

5

High-throughput

0.457

High

619371

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.457

High

619385

UTP13
U3 small nucleolar RNA-associated protein 13

1

5

High-throughput

0.457

High

394218

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

525878

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.445

High

578812

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.445

High

383505

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

433434

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

434804

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

441692

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.437

High

454859

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

502837

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504027

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

512245

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

619329

TAH1
TPR repeat-containing protein associated with Hsp90

1

2

Small-scale

0.437

High

619333

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

619334

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

619335

BMH1
Protein BMH1

1

5

High-throughput

0.437

High

619344

IXR1
Intrastrand cross-link recognition protein

1

7

Small-scale

0.437

High

619345

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

619349

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.437

High

619355

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

619368

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

619373

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

619377

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.437

High

619379

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

619381

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.437

High

619383

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

619391

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

619374

IPI3
Pre-rRNA-processing protein IPI3

1

7

High-throughput

0.417

High

523005

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.407

High

591995

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

619338

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.407

High

619361

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.407

High

619365

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

531236

METK1
S-adenosylmethionine synthase 1

2

0

High-throughput

0.307

High

619375

CARME
Carnosine N-methyltransferase

1

0

High-throughput

0.282

High

432483

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.279

Low

619388

SHS1
Seventh homolog of septin 1

1

0

High-throughput

0.279

Low

619341

STE5
Protein STE5

1

0

High-throughput

0.269

Low

576932

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.261

Low

617929

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

0

High-throughput

0.261

Low

619346

SIP2
SNF1 protein kinase subunit beta-2

1

0

High-throughput

0.261

Low

619347

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.261

Low

619387

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

619390

RBX1
RING-box protein HRT1

1

0

High-throughput

0.261

Low

619392

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.261

Low

409925

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

503749

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.249

Low

511133

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

619328

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

619332

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

619348

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

619350

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

619372

ATP23
Mitochondrial inner membrane protease ATP23

1

0

High-throughput

0.249

Low

619386

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

High-throughput

0.249

Low

504661

YL21B
Transposon Ty2-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.232

Low

619369

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025