HitPredict

Interactor 1: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Interactor 2: SIR7 (Q9NRC8)
NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Gene: SIRT7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22586326
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2177 Hs			1 400
+	Hs
		1236427 MED12_HUMAN (1-2177): 0: 2488: 100.00		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1311999 DIDO1_HUMAN (1479-2099): 1.5e-18: 95.4: 10.74		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1017354 BPTF_HUMAN (1686-2176): 1.04e-14: 83.1: 11.51		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1344512 CHD7_HUMAN (1825-2174): 2.18e-10: 68.8: 10.05		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1236415 CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1236380 ARI1B_HUMAN (1839-2172): 5.1e-10: 67.3: 14.20		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1236444 EP400_HUMAN (1812-2174): 7.89e-09: 63.4: 17.63		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Mm
		70937 EP300_MOUSE (1845-2169): 2.28e-10: 68.7: 22.10		SIR1_MOUSE (78-380): 5.54e-78: 256: 19.94