HitPredict - High confidence protein-protein interactions

Interactor 1: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	26221961, 28934360, 34880843, 33110251, 19036819, 19193783, 24379373
Identification Methods	affinity chromatography technology, pull down, two hybrid, bioluminescence resonance energy transfer, anti tag coimmunoprecipitation, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CARD_2~CARD_2
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0002218 - activation of innate immune response GO:0002230 - positive regulation of defense response to virus by host GO:0002735 - positive regulation of myeloid dendritic cell cytokine production GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway and 37 others more... GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005778 - peroxisomal membrane GO:0007165 - signal transduction GO:0019901 - protein kinase binding GO:0030674 - protein-macromolecule adaptor activity GO:0031966 - mitochondrial membrane GO:0032481 - positive regulation of type I interferon production GO:0032727 - positive regulation of interferon-alpha production GO:0032728 - positive regulation of interferon-beta production GO:0032755 - positive regulation of interleukin-6 production GO:0032757 - positive regulation of interleukin-8 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0035556 - intracellular signal transduction GO:0035591 - signaling adaptor activity GO:0042307 - positive regulation of protein import into nucleus GO:0042742 - defense response to bacterium GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045071 - negative regulation of viral genome replication GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050700 - CARD domain binding GO:0051607 - defense response to virus GO:0060090 - molecular adaptor activity GO:0060337 - type I interferon-mediated signaling pathway GO:0060340 - positive regulation of type I interferon-mediated signaling pathway GO:0060760 - positive regulation of response to cytokine stimulus GO:0070585 - protein localization to mitochondrion GO:0071360 - cellular response to exogenous dsRNA GO:0071651 - positive regulation of chemokine (C-C motif) ligand 5 production GO:0071660 - positive regulation of IP-10 production GO:0120283 - protein serine/threonine kinase binding GO:0140297 - DNA-binding transcription factor binding GO:0140374 - antiviral innate immune response GO:0140693 - molecular condensate scaffold activity GO:1900063 - regulation of peroxisome organization GO:1900227 - positive regulation of NLRP3 inflammasome complex assembly
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	540
Hs

1	540

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Last updated: 11Aug2025