HitPredict

Interactor 1: IF2B3 (O00425)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
Gene: IGF2BP3

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35013218, 21150319
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010468 - regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 579 Hs			1 454
+	Hs
		348086 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		127979 IF2B3_HUMAN (1-579): 2.3e-149: 444: 100.00		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379960 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		346846 PCBP1_HUMAN (277-508): 3.85e-32: 129: 24.14		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		347530 FUBP1_HUMAN (353-559): 5.1e-29: 123: 23.22		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346847 PCBP2_HUMAN (193-484): 7.41e-30: 122: 19.05		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		348394 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		347594 FUBP3_HUMAN (189-414): 5.52e-18: 89.3: 14.17		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346697 PABP4_HUMAN (73-346): 8e-14: 76.6: 9.03		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		347503 FUBP2_HUMAN (426-567): 1e-12: 73.1: 16.90		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		345797 PABP1_HUMAN (74-346): 1.06e-11: 69.6: 8.30		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346354 PCBP3_HUMAN (134-272): 5.55e-10: 63.3: 20.86		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		379428 PCBP1_HUMAN (277-508): 3.85e-32: 129: 24.14		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379692 FUBP1_HUMAN (353-559): 5.1e-29: 123: 23.22		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379429 PCBP2_HUMAN (193-484): 7.41e-30: 122: 19.05		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		380081 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379728 FUBP3_HUMAN (189-414): 5.52e-18: 89.3: 14.17		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379365 PABP4_HUMAN (73-346): 8e-14: 76.6: 9.03		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379683 FUBP2_HUMAN (426-567): 1e-12: 73.1: 16.90		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		378957 PABP1_HUMAN (74-346): 1.06e-11: 69.6: 8.30		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40