Protein: CSN2
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)

Gene: CSN2, COPS2
Organism: Homo sapiens
Interactions: 186
UniProt ID: P61201

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000338 - protein deneddylation
GO:0001833 - inner cell mass cell proliferation
GO:0001834 - trophectodermal cell proliferation
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

958737

CSN3
COP9 signalosome complex subunit 3

17

18

Small-scale

0.985

High

958628

CSN1
COP9 signalosome complex subunit 1

17

17

Small-scale

0.985

High

958664

CSN6
COP9 signalosome complex subunit 6

12

20

Small-scale

0.979

High

958704

CSN4
COP9 signalosome complex subunit 4

11

20

Small-scale

0.974

High

958702

CSN8
COP9 signalosome complex subunit 8

10

10

Small-scale

0.972

High

958730

CSN7A
COP9 signalosome complex subunit 7a

9

20

Small-scale

0.970

High

958716

CSN7B
COP9 signalosome complex subunit 7b

8

20

Small-scale

0.965

High

127919

PSD11
26S proteasome non-ATPase regulatory subunit 11

2

19

High-throughput

0.783

High

958689

CSN5
COP9 signalosome complex subunit 5

18

20

Small-scale

0.764

High

958636

CUL4A
Cullin-4A

15

20

Small-scale

0.764

High

958635

CUL3
Cullin-3

12

20

Small-scale

0.758

High

958634

CUL2
Cullin-2

10

20

Small-scale

0.756

High

958637

CUL4B
Cullin-4B

9

20

Small-scale

0.756

High

958633

CUL1
Cullin-1

8

20

Small-scale

0.751

High

958683

DDB2
DNA damage-binding protein 2

7

9

Small-scale

0.742

High

958676

DCA11
DDB1- and CUL4-associated factor 11

5

5

High-throughput

0.712

High

958695

LLR1
Leucine-rich repeat protein 1

5

3

High-throughput

0.712

High

958678

DCAF4
DDB1- and CUL4-associated factor 4

4

5

High-throughput

0.691

High

958686

APBP2
Amyloid protein-binding protein 2

4

6

High-throughput

0.691

High

958691

FBX17
F-box only protein 17

4

5

High-throughput

0.691

High

958707

BTBD2
BTB/POZ domain-containing protein 2

4

20

High-throughput

0.691

High

958712

BTBD1
BTB/POZ domain-containing protein 1

4

20

High-throughput

0.691

High

958734

FEM1B
Protein fem-1 homolog B

4

3

High-throughput

0.691

High

958739

FBX7
F-box only protein 7

4

2

High-throughput

0.691

High

958648

DDB1
DNA damage-binding protein 1

4

4

Small-scale

0.689

High

958620

CSK21
Casein kinase II subunit alpha

3

8

Small-scale

0.674

High

958690

CUL5
Cullin-5

3

20

Small-scale

0.674

High

958629

ERCC8
DNA excision repair protein ERCC-8

4

9

Small-scale

0.672

High

957274

UBC12
NEDD8-conjugating enzyme Ubc12

3

5

High-throughput

0.667

High

958703

KLDC3
Kelch domain-containing protein 3

3

18

High-throughput

0.667

High

958645

STK11
Serine/threonine-protein kinase STK11

3

4

High-throughput

0.662

High

958657

KLH10
Kelch-like protein 10

3

19

High-throughput

0.662

High

958668

FXL14
F-box/LRR-repeat protein 14

3

3

High-throughput

0.662

High

958718

FBX6
F-box only protein 6

3

5

High-throughput

0.656

High

958652

DCAF6
DDB1- and CUL4-associated factor 6

3

14

High-throughput

0.650

High

958681

CSN9
COP9 signalosome complex subunit 9

3

2

Small-scale

0.650

High

958623

IRF8
Interferon regulatory factor 8

2

5

Small-scale

0.649

High

958615

CSN2
COP9 signalosome complex subunit 2

1

19

Small-scale

0.647

High

958728

KLH13
Kelch-like protein 13

3

20

High-throughput

0.643

High

50897

SYCE3
Synaptonemal complex central element protein 3

2

1

High-throughput

0.628

High

220687

DENR
Density-regulated protein

2

1

High-throughput

0.628

High

342399

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

3

High-throughput

0.628

High

958631

SKP2
S-phase kinase-associated protein 2

2

8

High-throughput

0.628

High

958665

DET1
DET1 homolog

2

2

High-throughput

0.628

High

949321

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

Small-scale

0.618

High

533265

THA
Thyroid hormone receptor alpha

2

6

Small-scale

0.614

High

958622

PRAME
Melanoma antigen preferentially expressed in tumors

2

3

High-throughput

0.611

High

958646

NEDD8
Ubiquitin-like protein NEDD8

2

7

Small-scale

0.611

High

958740

DCAF1
DDB1- and CUL4-associated factor 1

2

5

Small-scale

0.611

High

958699

SIN3A
Paired amphipathic helix protein Sin3a

2

1

Small-scale

0.606

High

958735

FBXL5
F-box/LRR-repeat protein 5

2

0

High-throughput

0.602

High

958667

FBX11
F-box only protein 11

2

1

High-throughput

0.601

High

958670

WDTC1
WD and tetratricopeptide repeats protein 1

2

14

High-throughput

0.601

High

958720

ZN446
Zinc finger protein 446

2

0

High-throughput

0.580

High

519896

ANDR
Androgen receptor

1

8

Small-scale

0.573

High

936693

NP1L1
Nucleosome assembly protein 1-like 1

1

1

Small-scale

0.573

High

318692

RHBT1
Rho-related BTB domain-containing protein 1

2

14

High-throughput

0.571

High

429628

JUN
Transcription factor Jun

2

9

Small-scale

0.571

High

958654

DCAF8
DDB1- and CUL4-associated factor 8

2

15

High-throughput

0.571

High

958700

CRBN
Protein cereblon

2

2

Small-scale

0.571

High

958708

RHBT2
Rho-related BTB domain-containing protein 2

2

14

High-throughput

0.571

High

958709

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

7

High-throughput

0.571

High

958724

DTL
Denticleless protein homolog

2

9

Small-scale

0.571

High

958625

EP300
Histone acetyltransferase p300

1

8

Small-scale

0.568

High

958696

SENP8
Sentrin-specific protease 8

1

1

Small-scale

0.561

High

958713

ING2
Inhibitor of growth protein 2

1

1

Small-scale

0.561

High

958733

ING1
Inhibitor of growth protein 1

1

1

Small-scale

0.561

High

958649

KLH12
Kelch-like protein 12

2

19

High-throughput

0.552

High

958711

NIF3L
NIF3-like protein 1

1

0

Small-scale

0.549

High

320819

KLH18
Kelch-like protein 18

1

19

High-throughput

0.536

High

385616

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.536

High

625281

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.536

High

958643

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

3

High-throughput

0.536

High

958660

KLH24
Kelch-like protein 24

1

19

High-throughput

0.536

High

958692

DCNL1
DCN1-like protein 1

1

2

High-throughput

0.536

High

958722

ASB6
Ankyrin repeat and SOCS box protein 6

1

3

High-throughput

0.536

High

958726

KLHL8
Kelch-like protein 8

1

19

High-throughput

0.536

High

938645

ALR
FAD-linked sulfhydryl oxidase ALR

1

1

Small-scale

0.534

High

958688

CBP
CREB-binding protein

1

8

Small-scale

0.534

High

958672

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

2

5

Small-scale

0.533

High

543485

VDR
Vitamin D3 receptor

1

8

Small-scale

0.527

High

908325

NR0B1
Nuclear receptor subfamily 0 group B member 1

1

3

Small-scale

0.527

High

958624

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

0

Small-scale

0.526

High

155098

SOCS2
Suppressor of cytokine signaling 2

1

2

High-throughput

0.515

High

683422

IKBA
NF-kappa-B inhibitor alpha

1

2

Small-scale

0.515

High

958729

WRP73
WD repeat-containing protein WRAP73

1

4

High-throughput

0.515

High

866962

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

958698

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.513

High

958721

PLAT2
Phospholipase A and acyltransferase 2

1

0

High-throughput

0.513

High

185573

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

274304

SIN3B
Paired amphipathic helix protein Sin3b

1

1

Small-scale

0.501

High

507761

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.501

High

522812

COT1
COUP transcription factor 1

1

2

Small-scale

0.501

High

958621

H31
Histone H3.1

1

1

Small-scale

0.501

High

958641

KPCD1
Serine/threonine-protein kinase D1

1

2

Small-scale

0.501

High

958684

IP6K1
Inositol hexakisphosphate kinase 1

1

1

Small-scale

0.501

High

301387

WFS1
Wolframin

1

0

High-throughput

0.493

High

50364

PXDNL
Probable oxidoreductase PXDNL

1

1

High-throughput

0.489

High

958651

ANR39
Ankyrin repeat domain-containing protein 39

1

5

High-throughput

0.489

High

958671

SYT2
Synaptotagmin-2

1

1

High-throughput

0.489

High

533333

THB
Thyroid hormone receptor beta

1

6

Small-scale

0.481

High

958687

RND1
Rho-related GTP-binding protein Rho6

1

5

Small-scale

0.481

High

278291

NCOR1
Nuclear receptor corepressor 1

1

0

Small-scale

0.480

High

958618

H4
Histone H4

1

0

Small-scale

0.480

High

136864

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

241266

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

258266

TRI13
E3 ubiquitin-protein ligase TRIM13

1

6

High-throughput

0.479

High

259710

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

279325

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

315363

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

413516

P53
Cellular tumor antigen p53

1

3

Small-scale

0.479

High

445803

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

446827

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

588364

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

610285

PRS6A
26S proteasome regulatory subunit 6A

1

20

Small-scale

0.479

High

695096

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

761969

GRK5
G protein-coupled receptor kinase 5

1

3

High-throughput

0.479

High

767853

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

830463

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

945566

FBXW4
F-box/WD repeat-containing protein 4

1

7

Small-scale

0.479

High

954777

PSA6
Proteasome subunit alpha type-6

1

20

Small-scale

0.479

High

958616

PRS4
26S proteasome regulatory subunit 4

1

20

Small-scale

0.479

High

958617

PRS8
26S proteasome regulatory subunit 8

1

20

Small-scale

0.479

High

958619

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

High-throughput

0.479

High

958626

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

4

Small-scale

0.479

High

958627

CDC16
Cell division cycle protein 16 homolog

1

6

Small-scale

0.479

High

958630

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

958632

IRF5
Interferon regulatory factor 5

1

5

Small-scale

0.479

High

958639

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

5

High-throughput

0.479

High

958642

ELOB
Elongin-B

1

2

High-throughput

0.479

High

958644

TRIPB
Thyroid receptor-interacting protein 11

1

1

Small-scale

0.479

High

958647

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

3

Small-scale

0.479

High

958656

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

958662

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

958666

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

958673

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

958674

COP1
E3 ubiquitin-protein ligase COP1

1

10

High-throughput

0.479

High

958680

PHIP
PH-interacting protein

1

5

Small-scale

0.479

High

958685

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.479

High

958705

DDA1
DET1- and DDB1-associated protein 1

1

2

High-throughput

0.479

High

958710

KLHL4
Kelch-like protein 4

1

20

High-throughput

0.479

High

958715

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

958723

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

958725

IBTK
Inhibitor of Bruton tyrosine kinase

1

7

Small-scale

0.479

High

958731

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

958732

APC4
Anaphase-promoting complex subunit 4

1

1

Small-scale

0.479

High

958736

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

Small-scale

0.479

High

958743

MAFB
Transcription factor MafB

1

11

High-throughput

0.479

High

958669

FBXL6
F-box/LRR-repeat protein 6

1

8

High-throughput

0.470

High

622789

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

Small-scale

0.458

High

684958

DNMT1
DNA

1

0

Small-scale

0.458

High

958638

TF2H2
General transcription factor IIH subunit 2

1

0

Small-scale

0.458

High

958714

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.458

High

958717

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.458

High

958701

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.457

High

127039

APBB1
Amyloid beta precursor protein binding family B member 1

1

3

High-throughput

0.445

High

529484

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

848364

MAGA6
Melanoma-associated antigen 6

1

3

High-throughput

0.445

High

958640

LRC14
Leucine-rich repeat-containing protein 14

1

3

High-throughput

0.445

High

958650

KLH22
Kelch-like protein 22

1

20

High-throughput

0.445

High

958653

DCA10
DDB1- and CUL4-associated factor 10

1

3

High-throughput

0.445

High

958679

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

20

High-throughput

0.445

High

958697

KLH15
Kelch-like protein 15

1

20

High-throughput

0.445

High

958706

CAR10
Caspase recruitment domain-containing protein 10

1

1

High-throughput

0.445

High

958727

KLH42
Kelch-like protein 42

1

20

High-throughput

0.445

High

958738

KLDC2
Kelch domain-containing protein 2

1

20

High-throughput

0.445

High

958741

ASB1
Ankyrin repeat and SOCS box protein 1

1

9

High-throughput

0.445

High

128505

RN103
E3 ubiquitin-protein ligase RNF103

1

4

High-throughput

0.437

High

958658

FBX42
F-box only protein 42

1

5

High-throughput

0.437

High

958659

FBX38
F-box only protein 38

1

0

High-throughput

0.426

High

958677

ARB2A
Cotranscriptional regulator ARB2A

1

0

High-throughput

0.426

High

958719

PCMD2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

1

0

High-throughput

0.426

High

62482

S35F4
Solute carrier family 35 member F4

1

2

High-throughput

0.407

High

958655

DC121
DDB1- and CUL4-associated factor 12-like protein 1

1

1

High-throughput

0.407

High

958663

KCTD9
BTB/POZ domain-containing protein KCTD9

1

8

High-throughput

0.407

High

958675

SHKB1
SH3KBP1-binding protein 1

1

10

High-throughput

0.407

High

958742

KCTD3
BTB/POZ domain-containing protein KCTD3

1

8

High-throughput

0.407

High

338002

ABCA1
Phospholipid-transporting ATPase ABCA1

2

0

Small-scale

0.305

High

900752

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.279

Low

958682

RB40A
Ras-related protein Rab-40A

1

0

High-throughput

0.279

Low

890938

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.268

Low

958661

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.249

Low

958693

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.249

Low

516087

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

958694

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025